… These data suggest a molecular mechanism for Lin-14p temporal gradient formation: the
lin-4 RNAs base pair to sites in the lin.14 3’UTR to form multiple RNA duplexes that down-…

… types of lin-4 binding sites in temporal gradient formation, we … nonbulged lin-4 binding sites
(Fig. 4A). These multimerized … gene lin-14 by fin-4 mediates temporal pattern formation in C…

… engineering technique leads to well-de"ned pattern formation in a variety of cell types. …
Formation of cell arrays Several types of culture cells were used to study pattern formations. The …

… It is, therefore, possible that LIN-41 may also control translation of pattern formation … lin-41.
We therefore hypothesize that the regulation of lin-41 by the miRNAs let-7 and mir-125a/b/lin-4…

… in the retarded heterochronic mutants lin-4 and lin-14 gain-of-function (gf). In these
mutants, lin-14 escapes negative regulation by lin-4, and consequently lin-14 protein remains …

… of lin-42 are identified that expand our view of the lin-42 locus and significantly extend the
homology between LIN-… to PER proteins, LIN-42 has a dynamic expression pattern; its levels …

… We examined more carefully the normal expression pattern of GATA4 during this critical
time point of ventral closure and found that GATA4 mRNA was highly localized to the posterior …

… in response to the accumulation of lin-4 RNA. Our results indicate that association of lin-4
RNA with the 3 UTR of lin-14 mRNA permits normal biogenesis of lin-14 mRNA, and normal …

… pattern of tim-1 mRNA accumulation parallels that of lin-42. Unlike coordinated per andtim
expression in flies, the worm timelessexpression pattern was distinguishable from that of lin-…

… that the heterochronic gene lin-14, which controls the timing of stage-specific cell lineages
4 , 5 , … the expression pattern of Punc-25-SNB–GFP in lin-14(lf) mutants. Because existing …