… and development. In this mini-review, the concept and methodology of PBPK modeling
are briefly introduced. Several case studies were discussed on how PBPK modeling and …

… developed; 3) establish how model quality is assessed; and 4) provide a list of publically
available PBPK models … applications of PBPK modeling, how models are typically developed, …

… PBPK model building, a PBPK model for ciprofloxacin will be constructed and coupled to a
pharmacodynamic model … In order to illustrate the various steps of PBPK model development …

… Physiologically based pharmacokinetic (PBPK) modelling can be used to answer a number
… discovery and development and is thus becoming a very popular tool. PBPK models provide …

… PBPK models allow the early integration of a wide variety of … Use of PBPK models allows the
experimenter to gain insights … on using PBPK methodologies at the lead development stage …

… in the use and development of pediatric PBPK models will inevitably … for development of
a pediatric PBPK model incorporating existing adult drug data. Using this approach, the model …

… Highlight of these guidance is the application of PBPK model development that aid in …
Isosorbide mononitrate/IR [60] I Evaluate if rapid release is crucial for BE PBPK model developed …

… The PBPK models developed to date for nanoparticles are … animals, which are called “whole
body” PBPK models. These … recommendations on PBPK model development strategies, …

… of drug development. The objective of this review is, therefore, to define the accuracy of
PBPK model prediction and its utility throughout the phases of oncology drug development. …

… related to the development of a pediatric or neonatal PBPK model. We … PBPK models for
neonatal drug development, we performed a PubMed search (14 July 2018) with ‘PBPK model’ …