Geniposide, a novel agonist for GLP-1 receptor, prevents PC12 cells from oxidative damage via MAP kinase pathway
J Liu, F Yin, X Zheng, J Jing, Y Hu - Neurochemistry international, 2007 - Elsevier
… GLP-1 receptor involved in oxidative stress, we studied the influence of geniposide on the
PC12 cells … activity of the GLP-1 receptor on PC12 cells in our current experimental conditions. …
PC12 cells … activity of the GLP-1 receptor on PC12 cells in our current experimental conditions. …
GLP-1 receptor regulates cell growth through regulating IDE expression level in Aβ1–42-treated PC12 cells
H Li, L Cao, Y Ren, Y Jiang, W Xie, D Li - Bioscience Reports, 2018 - portlandpress.com
… was analyzed by MTT assay and apoptosis of PC12 cells was detected by flow cytometry. …
inhibiting cell viability and prompting cell apoptosis of PC12 cells. However, GLP-1R agonist …
inhibiting cell viability and prompting cell apoptosis of PC12 cells. However, GLP-1R agonist …
Glucagon-like peptide-1 (GLP-1) protects against methylglyoxal-induced PC12 cell apoptosis through the PI3K/Akt/mTOR/GCLc/redox signaling pathway
R Kimura, M Okouchi, H Fujioka, A Ichiyanagi, F Ryuge… - Neuroscience, 2009 - Elsevier
… PC12 cell line in order to identify protective action of GLP-1 for neural cell in diabetic state. …
in the protective action of GLP-1 on MG-induced PC12 cell apoptosis. Our results confirmed …
in the protective action of GLP-1 on MG-induced PC12 cell apoptosis. Our results confirmed …
A novel neurotrophic property of glucagon-like peptide 1: a promoter of nerve growth factor-mediated differentiation in PC12 cells
TA Perry, DK Lahiri, D Chen, JIE Zhou… - … of Pharmacology and …, 2002 - ASPET
… that GLP-1 might affect the proliferation of PC12 cells in culture. To clarify this issue, we
assessed cell … This study has demonstrated that PC12 cells express functional GLP-1 receptors. …
assessed cell … This study has demonstrated that PC12 cells express functional GLP-1 receptors. …
Epidermal growth factor receptor transactivation is necessary for glucagon-like peptide-1 to protect PC12 cells from apoptosis
R Kimura, M Okouchi, T Kato, K Imaeda… - …, 2013 - karger.com
… of PC12 cells to GLP-1 induces EGFR phosphorylation and that this effect was inhibited by
prior exposure of the cells to … GLP-1 receptors (GLP-1R) are widely expressed in the CNS, …
prior exposure of the cells to … GLP-1 receptors (GLP-1R) are widely expressed in the CNS, …
Neurotrophic property of geniposide for inducing the neuronal differentiation of PC12 cells
J Liu, X Zheng, F Yin, Y Hu, L Guo… - International Journal …, 2006 - Wiley Online Library
… Here, with the model of high throughput screen for GLP-1 receptor agonists, we screen and
… GLP-1 receptor. Furthermore, geniposide induces the neuronal differentiation of PC12 cells …
… GLP-1 receptor. Furthermore, geniposide induces the neuronal differentiation of PC12 cells …
[HTML][HTML] GLP-1 receptor plays a critical role in geniposide-induced expression of heme oxygenase-1 in PC12 cells
F Yin, J Liu, X Zheng, L Guo - Acta Pharmacologica Sinica, 2010 - nature.com
… of GLP-1R by geniposide in PC12 cells, we measured cell viability after … 1), geniposide
prevented PC12 cells from SIN-1-induced oxidative damage, and the cytoprotection of PC12 cells …
prevented PC12 cells from SIN-1-induced oxidative damage, and the cytoprotection of PC12 cells …
Glucagon-like peptide-1 (GLP-1) diminishes neuronal degeneration and death caused by NGF deprivation by suppressing Bim induction
… We report that GLP-1 provides sustained protection of cultured neuronal PC12 cells and …
peptide in PC12 cells, we tested higher doses of GLP-1. As shown in Fig. 2, higher doses of …
peptide in PC12 cells, we tested higher doses of GLP-1. As shown in Fig. 2, higher doses of …
Enhancing the GLP‐1 receptor signaling pathway leads to proliferation and neuroprotection in human neuroblastoma cells
Y Li, D Tweedie, MP Mattson… - Journal of …, 2010 - Wiley Online Library
… activation is neurotrophic, inducing neurite outgrowth in PC12 pheochromocytoma cells,
and neuroprotective, rescuing cultured neurons from various toxic insults, including glutamate-, …
and neuroprotective, rescuing cultured neurons from various toxic insults, including glutamate-, …
[HTML][HTML] Exendin-4 protects Aβ (1-42) oligomer-induced PC12 cell apoptosis
C Qiu, YP Wang, XD Pan, XY Liu, Z Chen… - American Journal of …, 2016 - ncbi.nlm.nih.gov
… -β(1-42) oligomers to induce PC12 cells and establish a model of neuronal apoptosis.
Amyloid-β(1-42… On this basis, Ex-4 (a GLP-1 receptor agonist) was used to intervene in PC12 cells …
Amyloid-β(1-42… On this basis, Ex-4 (a GLP-1 receptor agonist) was used to intervene in PC12 cells …
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