Adipose mesenchymal stem cell‐derived exosomes enhance PC12 cell function through the activation of the PI3K/AKT pathway

Y Xie, Y Chen, Y Zhu, X Chen, T Lin… - Stem Cells …, 2021 - Wiley Online Library
… of PI3K/AKT in PC12 cells. (a) The expression levels of p-PI3K and p-AKT were analyzed in
PC12 cells with … (b) The ADSC-exo-induced levels of p-PI3K and p-AKT were interrupted by …

Neuroprotective Effect of Fucoidan on H2O2-Induced Apoptosis in PC12 Cells Via Activation of PI3K/Akt Pathway

Y Gao, C Dong, J Yin, J Shen, J Tian, C Li - Cellular and molecular …, 2012 - Springer
… in cells pretreated with fucoidan were further elevated. Moreover, to dissect the role of fucoidan
in protecting PC12 against H 2 O 2 injury, LY294002, a PI3K … (cell viability), inhibited Akt

Isorhynchophylline protects PC12 cells against beta‐amyloid‐induced apoptosis via PI3K/Akt signaling pathway

YF Xian, ZX Lin, QQ Mao, JN Chen… - Evidence‐Based …, 2013 - Wiley Online Library
PC12 cells against the Aβ 25–35 -induced neurotoxicity via PI3K/Akt/GSK-3β signaling
pathway… decreased the protein level of p-Akt (Ser473) in PC12 cells. Pretreatment with IRN could …

Asiatic acid protects differentiated PC12 cells from Aβ25–35-induced apoptosis and tau hyperphosphorylation via regulating PI3K/Akt/GSK-3β signaling

W Cheng, W Chen, P Wang, J Chu - Life Sciences, 2018 - Elsevier
PC12 cells from Aβ 25–35 -induced apoptosis and tau protein hyperphosphorylation,
which might be partially mediated by the activation of the PI3K/Akt/GSK-3β signaling pathway. …

Glucagon-like peptide-1 (GLP-1) protects against methylglyoxal-induced PC12 cell apoptosis through the PI3K/Akt/mTOR/GCLc/redox signaling pathway

R Kimura, M Okouchi, H Fujioka, A Ichiyanagi, F Ryuge… - Neuroscience, 2009 - Elsevier
PC12 cells were exposed to 1 mM methylglyoxal (MG) or MG plus 3.30 μg/ml GLP-1. …
in PC12 cell line in order to identify protective action of GLP-1 for neural cell in diabetic state. …

Nerve Growth Factor Protects Against Alcohol-Induced Neurotoxicity in PC12 Cells via PI3K/Akt/mTOR Pathway

L Liu, T Sun, F Xin, W Cui, J Guo, J Hu - Alcohol and Alcoholism, 2016 - academic.oup.com
… Therefore, we hypothesized that PI3K/Akt/mTOR pathway may be implicated in alcohol …
treatment in PC12 cells. Our results show that the phosphorylation of PI3K/Akt/mTOR pathway is …

The phosphatidylinositol‐3 kinase (PI3K)‐Akt pathway suppresses neurite branch formation in NGF‐treated PC12 cells

M Higuchi, K Onishi, N Masuyama, Y Gotoh - Genes to Cells, 2003 - Wiley Online Library
… role of PI3K in neurite branching, we utilized PC12 cells as a model system, and examined
the effect of LY294002, a PI3K inhibitor, on NGF-induced neurite morphology in PC12 cells. …

[HTML][HTML] Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 …

C Zhang, C Li, S Chen, Z Li, X Jia, K Wang, J Bao… - Redox biology, 2017 - Elsevier
… in 6-OHDA-induced PC12 cells and zebrafish neurotoxic models. Our results … PC12 cells,
ie low dose BBR significantly increased the cell viability, while high dose BBR inhibited the cell

α‐Lipoic acid alleviates ferroptosis in the MPP+‐induced PC12 cells via activating the PI3K/Akt/Nrf2 pathway

L Liu, S Yang, H Wang - Cell Biology International, 2021 - Wiley Online Library
… role of PI3K/Akt/Nrf2, we first treated PC12 cells with a PI3K inhibitor LY294002, an Akt inhibitor
… the levels of p-PI3K, p-AKT, and Nrf2 using Western blot analysis. Markedly inhibited p-…

[HTML][HTML] Senegenin inhibits Aβ1-42-induced PC12 cells apoptosis and oxidative stress via activation of the PI3K/Akt signaling pathway

X Ren, J Zhang, Y Zhao, L Sun - Neuropsychiatric disease and …, 2022 - ncbi.nlm.nih.gov
… study, our results also showed that PC12 cells treated with Sen have been found … PI3K/Akt
pathway, so we speculate that the antioxidant effect of Sen may related with PI3K/Akt pathway