Puerarin induces the upregulation of glutathione levels and nuclear translocation of Nrf2 through PI3K/Akt/GSK-3β signaling events in PC12 cells exposed to lead
C Li, Z Pan, T Xu, C Zhang, Q Wu, Y Niu - Neurotoxicology and Teratology, 2014 - Elsevier
… PI3K/Akt signaling regulates GCLc expression in PC12 cells … a molecular link between Akt
signaling and oxidative stress … effect on Akt phosphorylation, suggesting that PI3K is located …
signaling and oxidative stress … effect on Akt phosphorylation, suggesting that PI3K is located …
Vina-Ginsenoside R4 from Panax ginseng Leaves Alleviates 6-OHDA-Induced Neurotoxicity in PC12 Cells Via the PI3K/Akt/GSK-3β Signaling Pathway
Y Luo, Y Jiang, Y He, T Shen, L Ji, F Li… - Journal of Agricultural …, 2020 - ACS Publications
… To confirm the effect of PI3K/Akt/GSK-3β in VGN4-mediated neuroprotection, PI3K siRNA
was incubated with PC12 cells before treatment with VGN4 and 6-OHDA. In our study, PI3K/Akt/…
was incubated with PC12 cells before treatment with VGN4 and 6-OHDA. In our study, PI3K/Akt/…
3′, 4′-Didemethylnobiletin induces phase II detoxification gene expression and modulates PI3K/Akt signaling in PC12 cells
… In this research we found that in serum-deprived PC12 cells, both NOB and DTF induced
ERK, JNK, and Akt activation, all of which, especially the last, may be essential for cell survival …
ERK, JNK, and Akt activation, all of which, especially the last, may be essential for cell survival …
… effect of phosphocreatine on oxidative stress and mitochondrial dysfunction induced apoptosis in vitro and in vivo: Involvement of dual PI3K/Akt and Nrf2/HO-1 …
H Li, Z Tang, P Chu, Y Song, Y Yang, B Sun… - Free Radical Biology …, 2018 - Elsevier
… We examined the phosphorylated and total expression levels of AKT, Nrf2 and HO-1 after
treated with PCr in PC12 cells by Western blotting assay. As shown in Fig. 6A, pretreatment …
treated with PCr in PC12 cells by Western blotting assay. As shown in Fig. 6A, pretreatment …
Cycloprodigiosin hydrochloride activates the Ras-PI3K-Akt pathway and suppresses protein synthesis inhibition-induced apoptosis in PC12 cells
K Kawauchi, K Tobiume, K Iwashita… - Bioscience …, 2008 - jstage.jst.go.jp
… apoptosis in several cancer cells and acts as an … cell death in PC12 cells, which is caused
by protein synthesis inhibitors cycloheximide and actinomycin D. cPrG-HCl activated Akt and …
by protein synthesis inhibitors cycloheximide and actinomycin D. cPrG-HCl activated Akt and …
Biatractylolide Modulates PI3K‐Akt‐GSK3β‐Dependent Pathways to Protect against Glutamate‐Induced Cell Damage in PC12 and SH‐SY5Y Cells
L Zhu, N Ning, Y Li, QF Zhang, YC Xie… - Evidence‐Based …, 2017 - Wiley Online Library
… was involved in protective effects of biatractylolide on glutamate-induced PC12 cells and
SH-SY5Y cells, we further analyze protein characterization using western blotting. Figures 8(a)–…
SH-SY5Y cells, we further analyze protein characterization using western blotting. Figures 8(a)–…
Resveratrol against 6-OHDA-induced damage of PC12 cells via PI3K/Akt
N Huang, J Huang, Y Zhang, M Chen… - Translational …, 2021 - degruyter.com
… 3.5 Res increased the expression of p-Akt-Ser473 in 6-OHDA-treated PC12 cells Ser473
is the major phosphorylation site of Akt, so we detected it in 6-OHDA-treated PC12 cells. As …
is the major phosphorylation site of Akt, so we detected it in 6-OHDA-treated PC12 cells. As …
… endoplasmic reticulum stress in recombinant human beta nerve growth factor–induced PC12 cells after mechanical injury via PI3K/AKT/mTOR signaling pathway
Z Wang, S Zheng, Y Gu, L Zhou, B Lin, W Liu - World Neurosurgery, 2020 - Elsevier
… Our study showed that NGF-induced PC12 cells can induce autophagy and ER stress after
… to PI3K inhibitor LY294002, enhanced autophagy via PI3K/AKT/mTOR signaling pathway. …
… to PI3K inhibitor LY294002, enhanced autophagy via PI3K/AKT/mTOR signaling pathway. …
β-Asarone ameliorates β-amyloid–induced neurotoxicity in PC12 cells by activating P13K/Akt/Nrf2 signaling pathway
M Meng, L Zhang, D Ai, H Wu, W Peng - Frontiers in pharmacology, 2021 - frontiersin.org
… by upregulating the level of PI3K/Akt phosphorylation. In conclusion, β-asarone could exert
neuroprotective effects by modulating the P13K/Akt/Nrf2 signaling pathway. β-asarone might …
neuroprotective effects by modulating the P13K/Akt/Nrf2 signaling pathway. β-asarone might …
Caffeic acid phenethyl ester (CAPE) protects PC12 cells against cisplatin-induced neurotoxicity by activating the AMPK/SIRT1, MAPK/Erk, and PI3k/Akt signaling …
RS Ferreira, NAG Dos Santos, CP Bernardes… - Neurotoxicity …, 2019 - Springer
… proteins (F-actin and β-III-tubulin) in PC12 cells pretreated with the inhibitor of the PI3K/Akt
pathway (LY294002) or the MAPK/Erk pathway (U0126). (a) Western blot bands. (b–c) Bar …
pathway (LY294002) or the MAPK/Erk pathway (U0126). (a) Western blot bands. (b–c) Bar …