Parthenolide attenuates cerebral ischemia/reperfusion injury via Akt/GSK-3β pathway in PC12 cells
J Zhang, L Zhang, L Shi, Z Zhao, H Xu, F Liang… - Biomedicine & …, 2017 - Elsevier
… p-Akt/Akt and p-GSK-3β/GSK-3β in PC12 cells exposed to OGD/R. … of p-Akt and p-GSK-3β
were significantly decreased in PC12 … Akt is a downstream kinase of PI3K that is activated by …
were significantly decreased in PC12 … Akt is a downstream kinase of PI3K that is activated by …
Involvement of Akt in preconditioning-induced tolerance to ischemia in PC12 cells
JA Hillion, YX Li, D Marie… - Journal of Cerebral …, 2006 - journals.sagepub.com
… PC12 cells, we addressed the question whether ischemic tolerance also downregulates Akt
in PC12 cells… role of the PI3K/Akt pathway in OGD-induced tolerance in PC12 cells. Our data …
in PC12 cells… role of the PI3K/Akt pathway in OGD-induced tolerance in PC12 cells. Our data …
Adipose-derived mesenchymal stem cells protect PC12 cells from glutamate excitotoxicity-induced apoptosis by upregulation of XIAP through PI3-K/Akt activation
S Lu, C Lu, Q Han, J Li, Z Du, L Liao, RC Zhao - Toxicology, 2011 - Elsevier
… pathway was more important to the neuroprotection of AMSC-CM, we used Western blot
analysis to determine p-Akt and p-ERK levels in the PC12 cells… Cross-talk between the PI3K/Akt …
analysis to determine p-Akt and p-ERK levels in the PC12 cells… Cross-talk between the PI3K/Akt …
Beta-asarone attenuates amyloid beta-induced autophagy via Akt/mTOR pathway in PC12 cells
Z Xue, Y Guo, S Zhang, L Huang, Y He, R Fang… - European Journal of …, 2014 - Elsevier
… PC12 cells. Furthermore, we investigated the regulating effects of β-asarone on Beclin-1,
p-Akt … ), autophagy activator rapamycin and PI3K-Akt-mTOR signaling pathway inhibitor NVP-…
p-Akt … ), autophagy activator rapamycin and PI3K-Akt-mTOR signaling pathway inhibitor NVP-…
Luteolin‑induced protection of H2O2‑induced apoptosis in PC12 cells and the associated pathway
P Lin, XH Tian, YS Yi, WS Jiang… - Molecular …, 2015 - spandidos-publications.com
… mediated through the PI3K/Akt pathway, PC12 cells were pretreated with LY294002, a
PI3K/Akt inhibitor. The results demonstrated that the effects of luteolin on p-Akt levels (Fig. 5A), …
PI3K/Akt inhibitor. The results demonstrated that the effects of luteolin on p-Akt levels (Fig. 5A), …
… effects of flavonoid fisetin against corticosterone-induced cell death through modulation of ERK, p38, and PI3K/Akt/FOXO3a-dependent pathways in PC12 cells
… of the PI3/Akt-FOXO3a pathway in corticosterone-treated PC12 cells. To explore this aspect,
the experiments were initiated by pre-treating PC12 cells with LY294002, followed by their …
the experiments were initiated by pre-treating PC12 cells with LY294002, followed by their …
[HTML][HTML] RP105 protects PC12 cells from oxygen‑glucose deprivation/reoxygenation injury via activation of the PI3K/AKT signaling pathway
… PI3K/AKT signaling as a substrate of RP105, it is of interest to examine the existence of an
RP105-PI3K-AKT … OGD/R-induced impairment of PC12 cells was markedly ameliorated by the …
RP105-PI3K-AKT … OGD/R-induced impairment of PC12 cells was markedly ameliorated by the …
[HTML][HTML] … acid, L-BAIBA, protects PC12 cells from hydrogen peroxide-induced oxidative stress and apoptosis via activation of the AMPK and PI3K/Akt pathway
T Minato, N Nakamura, T Saiki, M Miyabe, M Ito… - IBRO neuroscience …, 2022 - Elsevier
… PI3K/Akt. In conclusion, we demonstrated that L-BAIBA confers protection against oxidative
stress in PC12 cells by activating the AMPK and PI3K/Akt … of neuron-like cells and become a …
stress in PC12 cells by activating the AMPK and PI3K/Akt … of neuron-like cells and become a …
6 ′‐O‐Galloylpaeoniflorin Attenuates Cerebral Ischemia Reperfusion‐Induced Neuroinflammation and Oxidative Stress via PI3K/Akt/Nrf2 Activation
Z Wen, W Hou, W Wu, Y Zhao, X Dong… - … and cellular …, 2018 - Wiley Online Library
… Nrf2 activation through activating the PI3K/Akt pathway (Figure 3). Our results showed
that GPF administration elevated the p-PI3K and p-Akt levels in PC12 cells in a dose-dependent …
that GPF administration elevated the p-PI3K and p-Akt levels in PC12 cells in a dose-dependent …
Inhibition of neuronal phenotype by PTEN in PC12 cells
S Musatov, J Roberts, AI Brooks… - Proceedings of the …, 2004 - National Acad Sciences
… Whereas antagonism of the PI3K pathway is clearly a major function of … PC12 Cells
Overexpressing PTEN to NGF Treatment. To examine the effects of PTEN on differentiated PC12 cells…
Overexpressing PTEN to NGF Treatment. To examine the effects of PTEN on differentiated PC12 cells…