Parthenolide attenuates cerebral ischemia/reperfusion injury via Akt/GSK-3β pathway in PC12 cells

J Zhang, L Zhang, L Shi, Z Zhao, H Xu, F Liang… - Biomedicine & …, 2017 - Elsevier
… p-Akt/Akt and p-GSK-3β/GSK-3β in PC12 cells exposed to OGD/R. … of p-Akt and p-GSK-3β
were significantly decreased in PC12Akt is a downstream kinase of PI3K that is activated by …

Involvement of Akt in preconditioning-induced tolerance to ischemia in PC12 cells

JA Hillion, YX Li, D Marie… - Journal of Cerebral …, 2006 - journals.sagepub.com
PC12 cells, we addressed the question whether ischemic tolerance also downregulates Akt
in PC12 cells… role of the PI3K/Akt pathway in OGD-induced tolerance in PC12 cells. Our data …

Adipose-derived mesenchymal stem cells protect PC12 cells from glutamate excitotoxicity-induced apoptosis by upregulation of XIAP through PI3-K/Akt activation

S Lu, C Lu, Q Han, J Li, Z Du, L Liao, RC Zhao - Toxicology, 2011 - Elsevier
pathway was more important to the neuroprotection of AMSC-CM, we used Western blot
analysis to determine p-Akt and p-ERK levels in the PC12 cells… Cross-talk between the PI3K/Akt

Beta-asarone attenuates amyloid beta-induced autophagy via Akt/mTOR pathway in PC12 cells

Z Xue, Y Guo, S Zhang, L Huang, Y He, R Fang… - European Journal of …, 2014 - Elsevier
PC12 cells. Furthermore, we investigated the regulating effects of β-asarone on Beclin-1,
p-Akt … ), autophagy activator rapamycin and PI3K-Akt-mTOR signaling pathway inhibitor NVP-…

Luteolin‑induced protection of H2O2‑induced apoptosis in PC12 cells and the associated pathway

P Lin, XH Tian, YS Yi, WS Jiang… - Molecular …, 2015 - spandidos-publications.com
… mediated through the PI3K/Akt pathway, PC12 cells were pretreated with LY294002, a
PI3K/Akt inhibitor. The results demonstrated that the effects of luteolin on p-Akt levels (Fig. 5A), …

… effects of flavonoid fisetin against corticosterone-induced cell death through modulation of ERK, p38, and PI3K/Akt/FOXO3a-dependent pathways in PC12 cells

PR Chang, JW Liou, PY Chen, WY Gao, CL Wu, MJ Wu… - Pharmaceutics, 2023 - mdpi.com
… of the PI3/Akt-FOXO3a pathway in corticosterone-treated PC12 cells. To explore this aspect,
the experiments were initiated by pre-treating PC12 cells with LY294002, followed by their …

[HTML][HTML] RP105 protects PC12 cells from oxygen‑glucose deprivation/reoxygenation injury via activation of the PI3K/AKT signaling pathway

Y Sun, L Liu, J Yuan, Q Sun… - International …, 2018 - spandidos-publications.com
PI3K/AKT signaling as a substrate of RP105, it is of interest to examine the existence of an
RP105-PI3K-AKT … OGD/R-induced impairment of PC12 cells was markedly ameliorated by the …

[HTML][HTML] … acid, L-BAIBA, protects PC12 cells from hydrogen peroxide-induced oxidative stress and apoptosis via activation of the AMPK and PI3K/Akt pathway

T Minato, N Nakamura, T Saiki, M Miyabe, M Ito… - IBRO neuroscience …, 2022 - Elsevier
PI3K/Akt. In conclusion, we demonstrated that L-BAIBA confers protection against oxidative
stress in PC12 cells by activating the AMPK and PI3K/Akt … of neuron-like cells and become a …

6 O‐Galloylpaeoniflorin Attenuates Cerebral Ischemia Reperfusion‐Induced Neuroinflammation and Oxidative Stress via PI3K/Akt/Nrf2 Activation

Z Wen, W Hou, W Wu, Y Zhao, X Dong… - … and cellular …, 2018 - Wiley Online Library
… Nrf2 activation through activating the PI3K/Akt pathway (Figure 3). Our results showed
that GPF administration elevated the p-PI3K and p-Akt levels in PC12 cells in a dose-dependent …

Inhibition of neuronal phenotype by PTEN in PC12 cells

S Musatov, J Roberts, AI Brooks… - Proceedings of the …, 2004 - National Acad Sciences
… Whereas antagonism of the PI3K pathway is clearly a major function of … PC12 Cells
Overexpressing PTEN to NGF Treatment. To examine the effects of PTEN on differentiated PC12 cells