… We further found that patterns of PCAT-1 and PRC2 expression stratified patient tissues into
… of PCAT-1–repressed target genes. Taken together, our findings suggest that PCAT-1 is a …

… To pursue this hypothesis, we employed transcriptome sequencing on a cohort of 102 …
From a total of 1.723 billion sequence fragments from 201 lanes of sequencing (108 paired-…

… PCAT1 is a regulator of cell proliferation and a target of the Polycomb-Repressive Complex
… prostate cancers, we deep-sequenced transcriptomes of 12 benign prostatic hyperplasias (…

… Among these, we identified an uncharacterized two-exon, polyadenylated lncRNA, PCAT-1, …
modulation of PCAT-1 expression in vitro defined a core set of genes repressed by PCAT-1, …

… PCAT-1 as a prostate cancer lncRNA implicated in the regulation of DSB repair. We find that
PCAT-1 … Importantly, PCAT-1–expressing cells exhibit a BRCA-like phenotype, resulting in …

… all of the transcriptome-… transcriptome sequencing but lacked longer-term clinical outcomes.
To address this, we performed an integrative analysis of multiple independent transcriptome …

… PCAT-1 expression and the progression of CRC. In this study, the expression of PCAT-1 in
… Furthermore, the copy number variation of PCAT-1 was also measured in 17 tumor tissues …

… Also, the molecular mechanism of PCAT-1 has been revealed that PCAT-1 is directly linked
… ) to repress transcription and that PCAT-1 overexpression leads to cell proliferation induced …

… However, evidence from whole-genome and transcriptome sequencing suggests that the
complexity of an organism may be regulated by non-coding RNAs (ncRNAs) located in the non-…

… of cMyc by PCAT-1. This work establishes a basis for the oncogenic role of PCAT-1 in cancer
… basis of this unbiased whole-transcriptome analysis, we have previously nominated PCAT-…