… of Long-Term Evolocumab Use Among Asian Subjects―A Subgroup Analysis of the Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects …

AC Keech, K Oyama, PS Sever, M Tang… - Circulation …, 2021 - jstage.jst.go.jp
… (proprotein convertase subtilisin/kexin type 9) inhibitor can further reduce the risk of … PCSK9
inhibitors.Any concerns about efficacy and safety of PCSK9 inhibition specifically in Asian

Lack of ethnic differences in the pharmacokinetics and pharmacodynamics of evolocumab between Caucasian and Asian populations

C Wang, Q Zheng, M Zhang… - British Journal of Clinical …, 2019 - Wiley Online Library
PCSK9 inhibited the elimination of LDL-C. The decreasing … Since no Asian subjects with
hypercholesterolaemia were … the PCSK9 values of Asian hypercholesterolaemia subjects. The …

A potential long-acting LDL-cholesterol–lowering PCSK9 monoclonal antibody: randomized, placebo-controlled phase 1 studies

Y Cui, X Zhao, L Qi, X Li, Z Huang, G Yang, L Qian… - JACC: Asia, 2021 - jacc.org
… a PCSK9 inhibitor with … PCSK9 monoclonal antibodies have been approved in the clinic,
we are the first to report the clinical investigation of a novel and potential long-acting PCSK9

Challenges with PCSK9 Inhibitors Use in Asia Given Real-World Data Implications

K Uno-Eder - Journal of Atherosclerosis and Thrombosis, 2023 - jstage.jst.go.jp
Asia. Given the current state, driven to some degree by “ability and willingness to pay” for
PCSK9 inhibitors, … More than 5 years after the launch of PCSK9 inhibitors, we have realistic …

Real-world analyses of the treatment conditions in patients initiating proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor in Taiwan

PL Lin, YW Wu, CF Lin, HI Yeh, WT Chang… - … of Atherosclerosis and …, 2023 - jstage.jst.go.jp
… In Asia, data on the efficacy of PCSK9 inhibitors in real-world practice under the local or
national reimbursement criteria are still limited. This study aimed to describe the clinical …

Association of PCSK9 variants with the risk of atherosclerotic cardiovascular disease and variable responses to PCSK9 inhibitor therapy

C Krittanawong, M Khawaja, RS Rosenson… - Current problems in …, 2022 - Elsevier
… intron sequences of PCSK9 in the 32 subjects with the lowest … subjects 3363 Fluorogenic
5′-nucleotidase assays for the … PCSK9 E670G polymorphism should be considered in Asian

Effect of PCSK9 inhibitor on lipoprotein particles in patients with acute coronary syndromes

T Li, Y Zhang, H Cong - BMC Cardiovascular Disorders, 2021 - Springer
… Informed consents were obtained from all subjects. ACS patients … Compared to statin alone,
a combination therapy of PCSK9 inhibitor … particles subfractions in patients with ACS in Asia. …

Effects of PCSK9 inhibitors on other than low-density lipoprotein cholesterol lipid variables

TD Filippatos, A Kei, CV Rizos… - Journal of …, 2018 - journals.sagepub.com
… Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors significantly lower LDL-C …
The review presents the associated mechanisms of the beneficial effects of PCSK9 inhibitors

Lipoprotein (a) and benefit of PCSK9 inhibition in patients with nominally controlled LDL cholesterol

GG Schwartz, M Szarek, VA Bittner, R Diaz… - Journal of the American …, 2021 - jacc.org
… Patients in the lower LDL-C subgroup were more likely to be South American or Asian, to
have diabetes, and to be treated with high-intensity statins and had higher triglyceride and …

The evolving future of PCSK9 inhibitors

RS Rosenson, RA Hegele, S Fazio… - Journal of the American …, 2018 - jacc.org
… /kexin type 9 (PCSK9) provide insights into … target PCSK9 lower LDL cholesterol (LDL-C)
levels by 55% to 72% in different high-risk patient groups. Clinical trials with PCSK9 inhibitors