… -1 (PD-1) and PD-1 ligand (PD-L1) pathway. The aim of this review is to summarize the PD-1
and PD-L1 … The role of PD-1 and PD-L1 in T-cell immune suppression and the potential for …

… the proliferation and viability of T cells in the coculture. … of PD-1 + B cells. Together, our
investigation demonstrated that the PD-1 + B cells possessed regulatory capacity toward T cell …

… maintains PD-1 protein homeostasis by degrading incompletely glycosylated PD-1, thereby
preventing excessive T cell suppression. KLHL22-mediated degradation of PD-1 protein will …

… cell activation. Our aim was to determine how inflammation influences PD-1-mediated T cell
suppression… mononuclear cells showed an increase in the percentage of PD-1 + cells within …

… PD-1 expression. Taking these findings together, we propose a novel model in which PD-1
controls the anergy induction of CD8 + T cells … effector/memory differentiation of CD8 T cells. …

… PD-1 cell … PD-1 is expressed several times higher on the cell surface of tumor-infiltrating
effector lymphocytes compared to intratumoral Tregs. The PD-L1 expressed on brain tumor cells …

… suppression mediated by neutrophils via the PD-L1/PD-1 … our understanding of T cell
exhaustion in HIV-1 infection and … such as PD-L1/PD-1 in future therapeutic approaches in HIV-1-…

… that tumor-associated PD-L1 facilitates apoptosis of activated T cells (17) and … cells (4) to
mediate immune suppression. We now know that the effects of PD-L1 on immune suppression …

… PD-1 upregulated on T reg cells and its interaction with PD-1 … T cells as one cause for the
potent T cell suppression and … of PD-1 on T reg cells, in addition to that on exhausted T cells, …

… A profound knowledge of PDL1/PD1 mechanisms will surely uncover a … underlying
PD1-dependent T cell suppression in cancer. … in PD1-dependent T cell suppression in cancer (38). …