… In all of the following experiments, we therefore used 100 ng/mL PDGF-AA and 5 ng/mL
PDGF-CC and regularly verified their equipotent proliferative effect. Controls included non-…

… the PI3K pathway with LY294002, a specific inhibitor of PI3K… pathway was activated in NSCs
upon PDGF-AA stimulation and that the Erk1/2 signaling pathway was required for PDGF-AA…

… firstly screen out PDGF-AA as the most differentially expressed isoforms of PDGF after hypoxic…
Our results provide new evidence to support that PDGF/PDGF-AA played a positive role in …

… that the PI3K pathway, but not p38 MAPK, is involved in PDGF-induced … PI3K/Akt have crucial
roles in PDGF-induced Müller cell proliferation. The PI3K/Akt pathway also mediates PDGF-…

… the PDGF-β receptor-dependent PI3K/Akt signaling pathway and … Down-regulation of
hypoxiainduced PI3K/Akt … , whereas at peak PDGF-β receptor-dependent Akt activation, hypoxia …

… However, our results indicate that inhibition of Akt pathway induced by PDGF… PDGF-Rβ
downstream and Akt upstream, and thus, the enhanced proliferation may be attenuated. PI3K/Akt …

… interactions between these Akt phosphorylation targets and p53 are PDGF-AA-dependent …
of axial skeleton defects found in Pdgfra PI3K/PI3K embryos. Taken together, our findings …

… PDGF induced activation of Akt specifically through PI3K since Akt activation was completely
abolished by the PI3K … Additionally, PI3K/Akt pathways activated by PDGF were partially …

… This study shows that PDGF-BB induces oral mucosal fibroblasts to convert into myofibroblasts
through the PDGFR- β /PI3K/AKT signaling pathway, and promotes their proliferation, …

… PI3K/AKT dysregulation leads to numerous pathological … Although the PI3K/AKT pathway
is a key regulator for … of the PI3K/AKT pathway and paracrine secretion of PDGF-AA as its …