… PDGF in humans are, for the most part, PDGF-BB, PDGF-AA, and PDGF-AB, among the PDGF
isoforms PDGF… PDGF-AA, PDGF-AB, and PDGF-BB are already activated intracellularly by …

… PDGF isoforms in cultured rat VSMC and found that the PDGF-BB isoform was a potent mitogen,
whereas PDGFAA … We attributed a lack of mitogenic activity of PDGF-AA to the absence …

… factors, platelet-derived growth factor-AA (PDGF-AA), … SCs substantially expressed the
mRNAs of PDGF-AA, FGF-2, … Our results found that the concentration of PDGF-AA, FGF-2, …

… and the Akt-pathway upon stimulation with PDGF-AA in wt and Tg737orpk MEFs. Western
blot analysis showed that PDGFRα and Akt are activated, with the level of Akt phosphorylation …

… PI3K/Akt is triggered by PDGF-BB, and this pathway is involved in the anti-apoptotic effect of
PDGF-BB … route for various growth factors, including PDGF-BB (35). Docetaxel inhibited the …

… PI3K pathway in periosteal progenitors. The effects of platelet-derived growth factor (PDGF) …
Combined with our results that PDGF is able to induce phosphorylation of Akt to the greatest …

… showed that distinct pathways with opposing actions were activated by PDGF. … PDGF-BB/PDGFRβ-induced
MSC proliferation and differentiation. We demonstrate that MEK/Erk, PI3K/Akt …

… Our aim was to investigate the role of phosphatidylinositol 3‐kinase (PI3K), mitogen‐… and
sustained activation of Akt (a target of PI3K). Furthermore, inhibitors of PI3K (LY294002 and …

… We subsequently examined the time course of PDGFAA-dependent Akt phosphorylation
in E13.5 primary MEPM cells. These cells uniformly express PDGFRa as well as several …

… pathway through which PDGF-Rβ induces cofilin de-phosphorylation. We show that the
PI3K/PLCγ-PKC pathway links the activated PDGF-… in PDGF-enhanced collagen gel contraction. …