Glucagon‐like peptide1‐based therapies and cardiovascular disease: looking beyond glycaemic control

P Anagnostis, VG Athyros, F Adamidou… - Diabetes, Obesity …, 2011 - Wiley Online Library
… randomized placebo-controlled trials. This review discusses the role of GLP-1 on the
cardiovascular system and addresses the impact of GLP-1-based therapies on CVD outcomes. …

Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and β-cell function in type 2 diabetes: a parallel-group study

M Zander, S Madsbad, JL Madsen, JJ Holst - The Lancet, 2002 - thelancet.com
glycaemic control due to antidiabetic treatment. In our study, GLP-1 improved glycaemic control
… The weight loss within the GLP-1 group was significant but only reached ap value of 0·13 …

Emerging cardiovascular actions of the incretin hormone glucagon‐like peptide1: potential therapeutic benefits beyond glycaemic control?

DJ Grieve, RS Cassidy… - British journal of …, 2009 - Wiley Online Library
… of GLP-1 appears to be in relation to glycaemic control, there is growing evidence to suggest
that it may also play an important role in the cardiovascular system. GLP-1 receptors (GLP-…

Gastrointestinal actions of glucagon‐like peptide1‐based therapies: glycaemic control beyond the pancreas

MM Smits, L Tonneijck, MHA Muskiet… - Diabetes, Obesity …, 2016 - Wiley Online Library
… Long-term intensive glycaemic control reduces the risk of … shown a sustained effect on
glycaemic control of up to 3 years 56; … GLP-1 receptor agonists maintain glycaemic control for up to …

Improved glycaemic control with minimal hypoglycaemia and no weight change with the once‐daily human glucagon‐like peptide1 analogue liraglutide as add‐on to …

K Kaku, MF Rasmussen, P Clauson… - Diabetes, Obesity and …, 2010 - Wiley Online Library
… , but initial improvement in glycaemic control often wanes over time, … for T2DM would improve
glycaemic control and beta-cell … Glucagon-like peptide-1 (GLP-1) receptor agonists such as …

Subcutaneous glucagon-like peptide-1 improves postprandial glycaemic control over a 3-week period in patients with early type 2 diabetes

JF Todd, CMB EDWARDS, MA GHATEI… - Clinical …, 1998 - portlandpress.com
… The beneficial effect on glycaemic control demonstrated in the … -1 levels after the injection.
Further studies using longer acting GLP-1 analogues are required to assess whether GLP-1 is …

Near‐normalization of glycaemic control with glucagon‐like peptide1 receptor agonist treatment combined with exercise in patients with type 2 diabetes

P Mensberg, S Nyby, PG Jørgensen… - Diabetes, Obesity …, 2017 - Wiley Online Library
… effect of liraglutide on glycaemic control in the present … substantial improvement in glycaemic
control in the exercise … the lack of improvement in glycaemic control despite an expected …

Liraglutide, a once‐daily human glucagon‐like peptide 1 analogue, provides sustained improvements in glycaemic control and weight for 2 years as monotherapy …

A Garber, RR Henry, R Ratner, P Hale… - Diabetes, obesity …, 2011 - Wiley Online Library
Aims: Most treatments for type 2 diabetes fail over time, necessitating combination therapy.
We investigated the safety, tolerability and efficacy of liraglutide monotherapy compared with …

Glucagon‐like peptide1 in diabetes care: Can glycaemic control be achieved without nausea and vomiting?

T Borner, IC Tinsley, RP Doyle… - British journal of …, 2022 - Wiley Online Library
… Introduced less than two decades ago, glucagon-like peptide-1 receptor agonists rapidly …
by providing glycaemic control in tandem with weight loss. However, FDA-approved GLP-1

Glucagon‐like peptide1 (GLP‐1): a trial of treatment in non‐insulin‐dependent diabetes mellitus

JF Todd, JPH Wilding, CMB Edwards… - European journal of …, 1997 - Wiley Online Library
… –1. We have demonstrated a significant improvement in postprandial glycaemic control with
s/c GLP-1 … GLP-1 improves glycaemic control even in the absence of an insulinotropic effect …