… HLA-DR-peptide complexes with weakened MHC-peptide … important energetically of the
MHCII peptide side-chain binding … in the DM-MHCII peptide complexes as a result of the DM-…

… class II-peptide complexes may have become stabilized by endogenous DM long before …
data is that DM catalyzes the release of prebound peptides from class II molecules, allowing …

… determining susceptibility to HLA-DM-mediated peptide exchange and provide a molecular
mechanism for HLA-DM to efficiently target unstable MHCII-peptide complexes for editing …

… High-affinity DR/peptide complexes are thus protected from the action of DM by … DM–DR
complex. The resulting high-affinity DR/peptide complex has a low likelihood of rebinding DM …

… peptide might enable crystallization of the DM-DR1 complex by trapping of a short-lived DM-…
-length low-affinity peptide (CLIP Low ) and the linker between the peptide C terminus and …

… peptide release from LZ-stabilized DM/MHCII complexes and analyzed these results in
light of our recent findings with soluble DR/peptide complexes exposed to soluble DM ( …

… of DM on the half-life of the DR/peptide complexes, we used a quantitative high performance
size exclusion chromatography assay to measure dissociation of f-peptides … ) of soluble DM. …

… HLA-DM 25 . Here we have presented evidence that DM dissociates the peptide–MHC class
II complexes … MHC class II molecule and the peptide backbone. In our experimental design …

… The structure of the HLA-DO–HLA-DM complex shows that it blocks HLA-DM activity as a
substrate mimic. Alterations in the efficiency of DM-mediated peptide selection may contribute …

… (HLA)-DR1–peptide complexes, and examining their reactivities with DM, we propose that
DM … molecule into a conformation that is highly peptide receptive. A more rigid conformation, …