… An important extension of this work is the identification of MHC-restricted peptide epitopes
from the sequence of the intact protein. Because estab lishing a region of interest in large …

… peptide sizes and the good alignment of end positions of all peptides bound to the same
MHC… We applied SMM to a set of 9-mer peptides bound to the HLA-A2 MHC molecule. We …

… (called human leucocyte antigen HLA-DM in humans) catalyses the release of CLIP,
allowing other peptides to bind before the MHC molecule’s migration to the plasma membrane. …

… solely account for peptide binding to a class I MHC molecule. The molecular dynamics
method could be used as a complementary tool to T cell epitope predictionsfrom the primary …

… of 1698 epitopes, restricted to 33 distinct MHC-II molecules. … epitope source protein was split
into overlapping peptides of … For each MHC molecule, we show the total number of peptides, …

… Therefore, the prediction of T cell epitopes relies primarily on predicting MHC-peptide … to
predict peptide binding to MHC molecules, using different types of peptide binding data and …

… the true molecular mass of the peptide. Note that the peptide bound to H–2 molecules does
… epitopes between experiments with synthetic peptides and those with naturally processed …

… that can predict which peptides bind to a given MHC molecule. These algorithms … Peptides
bound to MHC molecules that trigger an immune response are referred to as T-cell epitopes…

… are more precisely known we will be able to even more accurately predict which proteinderived
peptides will be in vivo relevant CTL epitopes and might be selected for use in …

… We are aware that when using this definition of epitope/non-epitope some predictions will …
of MHC class I molecules is very specific, binding only a highly limited repertoire of peptides,1, …