… DM was able to catalyze peptide exchange on complexes containing CLIP in either … by
the fact that DM only binds to DR molecules following disengagement of the peptide N-terminus, …

… of peptide binding to the human class II MHC protein HLA-DR1, we find that HLA-DM catalyzes
peptide exchange by facilitating a conformational change in the peptide-bound complex, …

… The crystal structure of a MHC class II–HLA-DM complex explains how HLA-DM stabilizes
… promotes a rapid peptide exchange process that favors the highest-affinity ligands. HLA-DO …

… soluble ectodomain of HLA-DM has been determined to 2.5 Å resolution by X-ray crystallography.
HLA-DM has both peptide exchange activity and acts as a chaperone to peptide-free …

… We demonstrate that DM is out-competed by certain superantigens, and increasing solvent
… inhibits DM-induced peptide association. We suggest that DM mediates peptide exchange by …

… , the mechanism of HLA-DM-mediated peptide exchange has been studied intensively. Here…
how HLA-DM mediates peptide exchange and focus on two recent co-structures of HLA-DM …

… HLA-DM (DM) mediates exchange of peptides bound to … Although DM has been shown
to have two activities, peptide … which DM facilitates peptide exchange has remained elusive. …

… There is evidence that HLA-DM has a dual function to both stabilize an … peptide exchange
10 , as discussed below. Although the involvement of HLA-DM in promoting peptide exchange …

… Thus, exchange peptide generates a conformer of pDR1 which … peptide exchange and the
substrate for DM activity. The resolution of the intermediate favors the highest affinity peptide. …

… at HLA. We modeled how rapid transitions in the … HLA-peptide are modulated by HLA-DM
binding; HLA-DM stabilizes a rare active conformational state that facilitates peptide exchange […