[HTML][HTML] Self-assemble peptide biomaterials and their biomedical applications

J Chen, X Zou - Bioactive materials, 2019 - Elsevier
… alternative to eliminate thermal instability and contamination with … drive the peptide amphiphiles
to assemble into nanofibers, of … Dynamic covalent bonds were also induced into peptide

Tuning the matrix metalloproteinase-1 degradability of peptide amphiphile nanofibers through supramolecular engineering

Y Shi, DS Ferreira, J Banerjee, AR Pickford… - Biomaterials …, 2019 - pubs.rsc.org
… 2), which suggests, to some extent, the instability of PA2 nanofibers. The slightly twisted …
strong β-sheet nanofibers have slow dynamics and minimal structural instability as a result of the …

Coarse-grained molecular dynamics studies of the structure and stability of peptide-based drug amphiphile filaments

M Kang, H Cui, SM Loverde - Soft Matter, 2017 - pubs.rsc.org
peptide-amphiphiles, Lee et al. characterized the structure of IKVAV-peptide amphiphile
nanofibers … , demonstrating that the DA filament instability initiates from the end-cap of the drug …

Post-assembly α-helix to β-sheet structural transformation within SAF-p1/p2a peptide nanofibers

EK Roberts, KM Wong, EJ Lee, MM Le, DM Patel… - Soft Matter, 2018 - pubs.rsc.org
… Visualization of the SAF peptide nanofiber was done with VMD (Visual Molecular Dynamics
, 36 but we found that these experimental conditions promote instability of SAF-p1/p2a α-…

Self-Assembly of Stimuli-Responsive Hydrogel Nanostructures by Peptide Amphiphiles via Molecular Dynamics Simulations

HD Nguyen - Biophysical Journal, 2014 - cell.com
Peptide amphiphiles (PA), which have been known to self-assemble into nanostructures such
as cylindrical nanofibers … alkyl tail, a short peptide sequence for intermolecular hydrogen …

[HTML][HTML] The conjugation of nonsteroidal anti-inflammatory drugs (NSAID) to small peptides for generating multifunctional supramolecular nanofibers/hydrogels

J Li, Y Kuang, J Shi, Y Gao, J Zhou… - Beilstein journal of …, 2013 - beilstein-journals.org
… Scheme 1: The structures of the NSAIDs and peptides explored as the building blocks of …
These nanotubes form a poorly cross-linked network, which agrees with the instability of the …

… Antimicrobial Biomaterials: Integrating an Enzyme Degradation-Resistant Sequence into Self-Assembled Nanosystems to Overcome Stability Limitations of Peptide …

W Yu, X Guo, Q Li, X Li, Y Wei, C Shao, L Zhang… - Advanced Fiber …, 2024 - Springer
… The proteolytic and physiological instability that primarily hampers their effectiveness [11,12,…
peptide nanofiber templates. The highly stable, multifunctional self-assembling short peptide

Short peptide based self-assembled nanostructures: implications in drug delivery and tissue engineering

JJ Panda, VS Chauhan - Polymer Chemistry, 2014 - pubs.rsc.org
… Moreover, their proteolytic instability has also been a major … , into cylindrical nanofibers
using atomistic molecular dynamics … Self-assembling peptide nanofiber scaffolds with amino …

Structural dynamic of a self-assembling peptide d-EAK16 made of only D-amino acids

Z Luo, X Zhao, S Zhang - PloS one, 2008 - journals.plos.org
peptide chirality alone is not crucial for nanofiber formation. This is not surprising since
both peptides are made of the same amino acid isomers where every residue in the peptide is …

Self–assembled peptide nanostructures for biomedical applications: advantages and challenges

J Castillo-León, KB Andersen… - … science and engineering, 2011 - books.google.com
… Top) The peptide nanofibers that are … peptide nanofibers did not hinder cell growth. The
next step in this study will be to combine the sensing properties of the functionalized nanofibers