Enhanced tumor outgrowth after peptide vaccination. Functional deletion of tumor-specific CTL induced by peptide vaccination can lead to the inability to reject tumors.
… To test whether vaccination with synthetic peptides leads to protection against Ad5El -expressing
tumor cells, we vaccinated mice SC with a low dose of the Ad5E1 B peptide. This …
tumor cells, we vaccinated mice SC with a low dose of the Ad5E1 B peptide. This …
Enhancement of tumor outgrowth through CTL tolerization after peptide vaccination is avoided by peptide presentation on dendritic cells
REM Toes, EIH van der Voort… - The Journal of …, 1998 - journals.aai.org
… of the Ad5E1 peptide vaccine either through incorporation of the peptides into liposomes or
… through peptide vaccination in a clinical setting, we set out to define vaccine formulations …
… through peptide vaccination in a clinical setting, we set out to define vaccine formulations …
Peptide vaccination can lead to enhanced tumor growth through specific T-cell tolerance induction.
RE Toes, R Offringa, RJ Blom… - Proceedings of the …, 1996 - National Acad Sciences
… outgrowth of Ad5ElAexpressing tumor cells in normal immunocompetent mice. The inhibitory
effects of peptide vaccination … than tolerance and tumor outgrowth. Our results indicate that …
effects of peptide vaccination … than tolerance and tumor outgrowth. Our results indicate that …
Peptide vaccine induces enhanced tumor growth associated with apoptosis induction in CD8+ T cells
D Muraoka, T Kato, L Wang, Y Maeda… - The Journal of …, 2010 - journals.aai.org
… tumor outgrowth associated with peptide-induced tolerance (7, 8). However, the detailed
mechanism(s) for tolerance/activation induction by peptide vaccinations … -1 expressing tumors …
mechanism(s) for tolerance/activation induction by peptide vaccinations … -1 expressing tumors …
Dendritic cells as carriers for a cytotoxic T-lymphocyte epitope–based peptide vaccine in protection against a human papillomavirus type 16–induced tumor
MA Ossevoort, MCW Feltkamp… - Journal of …, 1995 - journals.lww.com
… (CTL) epitope-based peptide vaccine of human papillomavirus type 16 (HPV 16) E7 aa
49–57 elicit protection against outgrowth of HPV 16-transformed tumor cells (C3 cells) in B6 mice…
49–57 elicit protection against outgrowth of HPV 16-transformed tumor cells (C3 cells) in B6 mice…
Therapeutic peptide vaccine-induced CD8 T cells strongly modulate intratumoral macrophages required for tumor regression
TC van der Sluis, M Sluijter, S van Duikeren… - Cancer immunology …, 2015 - AACR
… Application of the CSF-1R inhibitor alone did not lead to any change in tumor outgrowth.
Depletion of intratumoral macrophages by PLX3397 resulted in survival curves that were …
Depletion of intratumoral macrophages by PLX3397 resulted in survival curves that were …
[HTML][HTML] Comparison of protein and peptide targeting for the development of a CD169-based vaccination strategy against melanoma
D Van Dinther, H Veninga, M Revet… - Frontiers in …, 2018 - frontiersin.org
… and that these T cell responses can reduce tumor outgrowth (14). Here, we compare the …
peptide is sufficient to induce long-term CD8 + T cell responses and to inhibit tumor outgrowth. …
peptide is sufficient to induce long-term CD8 + T cell responses and to inhibit tumor outgrowth. …
A new era in anticancer peptide vaccines
SA Perez, E von Hofe, NL Kallinteris, AD Gritzapis… - Cancer, 2010 - Wiley Online Library
… tumor-associated antigen (TAA) gene in the early 1990s,1 the concept of peptide vaccination
… highly effective in protecting vaccinated mice from the outgrowth of syngeneic gliomas or …
… highly effective in protecting vaccinated mice from the outgrowth of syngeneic gliomas or …
Peptide Vaccination Breaks Tolerance to HER-2/neu by Generating Vaccine-Specific FasL+ CD4+ T Cells: First Evidence for Intratumor Apoptotic Regulatory T Cells
AD Gritzapis, IF Voutsas, E Lekka, M Papamichail… - Cancer research, 2010 - AACR
… Our vaccine regimen also significantly delayed the outgrowth of mammary carcinomas in …
To evaluate TCR specificity and functional status of Th infiltrating tumors in our vaccinated triple …
To evaluate TCR specificity and functional status of Th infiltrating tumors in our vaccinated triple …
Dendritic cell/peptide cancer vaccines: clinical responsiveness and epitope spreading
E Ranieri, LS Kierstead, H Zarour… - Immunological …, 2000 - Taylor & Francis
… As a result, a broadened repertoire of anti-tumor effector T cells may then target tumor
lesions and prevent the outgrowth of single or limited “antigen-loss” tumor variants (8,9). …
lesions and prevent the outgrowth of single or limited “antigen-loss” tumor variants (8,9). …
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