Dendritic cell-targeted vaccines

L Cohn, L Delamarre - Frontiers in immunology, 2014 - frontiersin.org
… -cell responses requires the presentation of peptides derived from internalized antigen on
class I major histocompatibility complex molecules by dendritic cells … of vaccination is to deliver …

A Phase I/II trial comparing autologous dendritic cell vaccine pulsed either with personalized peptides (PEP-DC) or with tumor lysate (OC-DC) in patients with …

A Sarivalasis, C Boudousquié, K Balint… - Journal of translational …, 2019 - Springer
… either a novel vaccine consisting of autologous DCs pulsed with up to ten peptides (PEP-DC)…
or a sequential combination of a DC vaccine loaded with autologous oxidized tumor lysate (…

Vaccine delivery by penetratin: Mechanism of antigen presentation by dendritic cells

D Pouniotis, CK Tang, V Apostolopoulos… - Immunologic …, 2016 - Springer
cell-penetrating property of these peptides has been used to deliver antigenic peptide and
proteins into antigen-presenting cells including DCs for the development of vaccine delivery …

Therapeutic immunization with human immunodeficiency virus type 1 (HIV-1) peptide-loaded dendritic cells is safe and induces immunogenicity in HIV-1-infected …

NC Connolly, TL Whiteside, C Wilson… - Clinical and Vaccine …, 2008 - Am Soc Microbiol
… We therefore conducted a phase I, clinical safety trial of a dendritic cell (DC)-based vaccination
… Participants were randomized to receive autologous DC-HIV-1 peptide vaccines either …

Phase I trial of intravenous peptide-pulsed dendritic cells in patients with metastatic melanoma

R Lau, F Wang, G Jeffery, V Marty… - Journal of …, 2001 - journals.lww.com
dendritic cells (DC) derived by incubation of plastic-adherent peripheral blood mononuclear
cells (… for immunotherapy using vaccination and/or adoptive therapy with peptide-pulsed DC. …

… of cell-based tuberculosis vaccines: genetically modified dendritic cell vaccine is a much more potent activator of CD4 and CD8 T cells than peptide-or protein-loaded …

JI Malowany, S McCormick, M Santosuosso, X Zhang… - Molecular Therapy, 2006 - cell.com
dendritic cell (DC)-based vaccines have not been explored for immunization against
tuberculosis. A gene-modified DC vaccine … AdAg85A-transduced DC vaccine (AdAg85/DC) …

[HTML][HTML] Dendritic cells based immunotherapy

N Shang, M Figini, J Shangguan, B Wang… - American journal of …, 2017 - ncbi.nlm.nih.gov
… the induction of dendritic cell vaccine-induced antigenspecific T cells in advanced melanoma
… through CTL tolerization after peptide vaccination is avoided by peptide presentation on …

Vaccination with dendritic cells pulsed with peptides of myelin basic protein promotes functional recovery from spinal cord injury

E Hauben, A Gothilf, A Cohen, O Butovsky… - Journal of …, 2003 - Soc Neuroscience
… with myelin peptides, it evokes an adaptive immune response directed to peptides of MBP. …
can be viewed as a DC vaccination and, like vaccination with the peptide in adjuvant, is a …

Long-term outcomes in patients with metastatic melanoma vaccinated with melanoma peptide-pulsed CD34+ progenitor-derived dendritic cells

JW Fay, AK Palucka, S Paczesny, M Dhodapkar… - Cancer Immunology …, 2006 - Springer
… of PBMCs to peptide reflects the presence of peptide-specific T cells, we measured the
frequency of CD8 + T cells binding MHC class I tetramers containing vaccine peptides (Fig. 1 and …

Dendritic cells process synthetic long peptides better than whole protein, improving antigen presentation and T‐cell activation

RA Rosalia, ED Quakkelaar, A Redeker… - European journal of …, 2013 - Wiley Online Library
… to long peptide vaccines, vaccinations with soluble … T-cell responses and low specific CD8
+ T-cell responses. Relatively poor potency of protein-based vaccines to induce CD8 + T-cell