The roles of perineuronal nets and the perinodal extracellular matrix in neuronal function

JW Fawcett, T Oohashi, T Pizzorusso - Nature Reviews Neuroscience, 2019 - nature.com
… a,b | Wisteria floribunda agglutinin (WFA) lectin staining of perineuronal nets (PNNs) in
the rat hippocampus (part a) and cortex (part b), showing the dense extracellular matrix coat …

The extracellular matrix and perineuronal nets in memory

JW Fawcett, M Fyhn, P Jendelova, JCF Kwok… - Molecular …, 2022 - nature.com
… , self-assembling into aggregate structures called perineuronal nets (PNNs) [12,13,14]. The
… , perineuronal nets (PNNs) with a cartilage-like structure surround some classes of neurons. …

Neuron‐glia interactions in neural plasticity: contributions of neural extracellular matrix and perineuronal nets

E Dzyubenko, C Gottschling, A Faissner - Neural plasticity, 2016 - Wiley Online Library
… the interface between the astrocyte and subsets of neurons in the vicinity of the synapse. …
neural ECM in neuropsychiatric diseases. Here, we highlight current concepts relating to neural

Deconstructing the perineuronal net: cellular contributions and molecular composition of the neuronal extracellular matrix

KA Giamanco, RT Matthews - Neuroscience, 2012 - Elsevier
Perineuronal nets (PNNs) are lattice-like substructures of the neural extracellular matrix that
enwrap particular populations of neurons throughout the central nervous system. Previous …

Extracellular matrix and perineuronal nets in CNS repair

JCF Kwok, G Dick, D Wang… - Developmental …, 2011 - Wiley Online Library
… in sub-populations of neurons [Fig. 1(A)]. CSPGs in the extracellular space interact with the
… This layer of organized matrix appears as a coat on the neuronal surface, and, as we will …

The perineuronal net component of the extracellular matrix in plasticity and epilepsy

PA McRae, BE Porter - Neurochemistry international, 2012 - Elsevier
… During development neuronal activity is required for perineuronal net expression. ►
Perineuronal netExtracellular matrix and perineuronal net are altered during epileptogenesis. …

… neurons, which lack four crucial extracellular matrix molecules, display abnormalities of synaptic structure and function and severe deficits in perineuronal net …

M Geissler, C Gottschling, A Aguado… - Journal of …, 2013 - Soc Neuroscience
… The extracellular matrix (ECM) of the brain plays crucial roles during the development, … In
a subpopulation of neurons, the ECM condenses to superstructures called perineuronal nets (…

Axon initial segment ensheathed by extracellular matrix in perineuronal nets

G Brückner, S Szeöke, S Pavlica, J Grosche, J Kacza - Neuroscience, 2006 - Elsevier
… used to analyze perineuronal nets associated with … perineuronal nets was divergent
between neurons but was identical around the different cellular domains of the individual neurons

Activity‐dependent formation and functions of chondroitin sulfate‐rich extracellular matrix of perineuronal nets

A Dityatev, G Brückner, G Dityateva… - Developmental …, 2007 - Wiley Online Library
… ABSTRACT: Extracellular matrix molecules—including … in perineuronal nets (PNs) associated
with subsets of neurons in … cell type-dependent extracellular matrix aggregates are formed …

Protective properties of neural extracellular matrix

A Suttkus, M Morawski, T Arendt - Molecular neurobiology, 2016 - Springer
… -called perineuronal net ensheathing a subtype of neurons. Here, we will give an overview
on recently emerging aspects of neuroprotective properties of CSPGs and perineuronal nets