… In conclusion, the ECM and PNNs are important regulators of CNS plasticity, both during
development and into adulthood. There is increasing evidence suggesting that production of …

… Perineuronal nets (PNNs) are reticular structures … central nervous system (CNS). PNN
formation is first detected relatively late in development, as the mature synaptic circuitry of the CNS …

… is remarkably dynamic, changing its plasticity-associated conditions, including … perineuronal
nets contribute to the maturation of brain circuits and the regulation of adult brain plasticity …

… of intercellular interaction in the CNS. In a subpopulation of neurons ECM develops into a
specific formation termed perineuronal nets [20, 21]. Perineuronal nets (PNNs) were described …

… as neuronal proliferation and migration, and network plasticity as … the perineuronal nets
(PNNs) that surround neuronal somata… Although PNNs in the adult CNS are generally stable …

… In conclusion, recent discoveries show that PNN formation contributes to a loss of brain
plasticity in adults, and that brain and spinal cord plasticity can be reestablished in adults after …

… perineuronal nets (PNNs) is attracting attention as a central mechanism controlling brain
plasticity… roles as both a regulator of synaptic plasticity and a protective barrier. PNNs have a …

… PNN regulation of experiencedependent cortical plasticity. In summary, PNNs function as
a critical factor that restricts CNS plasticity perhaps through several different molecular mecha…

… In light of evidence showing restriction of structural and functional plasticity mediated by
PNNs in the mature CNS, we hypothesized that changes in cortical PNN CSPGs integrity after …

… Plasticity in the CNS can be reactivated in the adult CNS by treatment with chondroitinase
… Plasticity in the adult CNS is restricted by perineuronal nets (PNNs) around many neuronal …