… Perineuronal nets (PNNs) are specialised extracellular matrix structures which … plasticity
and could relate to JNK signalling. Finally, we highlight that BDNF regulation of plasticity and …

… is thought to be involved in limiting neuronal plasticity, undergo changes in density … neuron
types that were examined. We propose that early age-related changes in neuronal plasticity …

… in the developing brain. This strategic localization positions them effectively to regulate
PNN-mediated neuronal plasticity within and potentially beyond critical periods of plasticity. …

… critical periods of heightened plasticity, when neuronal circuits are refined, and restrict
neural plasticity in the adult brain (1). A central part of this refinement of neuronal circuits is the …

… These studies suggest a variety of ways by which PNN disruption can effectuate the synaptic
plasticity. Perineuronal nets and interstitial matrix are by and large composed of the same …

… of plasticity. Closure of critical, or sensitive, periods in sensory cortices coincides with
perineuronal net (PNN) … in the pattern of maximal plasticity between the sexes during …

… At the end of development, neural plasticity and new learning … of perineuronal nets (PNN)
is one of the mechanisms that contribute to the closing of sensitive periods for neural plasticity …

… are established during neuronal maturation and, once formed, may oppose synaptic plasticity,
… The fact that PNs can be regulated by neuronal activity also suggests that they have an …

… ECM acts as a non-specific physical barrier that modulates neuronal plasticity and …
perineuronal nets. This review presents the current knowledge about the role of important neuronal …

… Recent studies have focused on the mechanisms underlying the regulation of neural plasticity
by the PNN. For instance, Beurdeley et al. (2012) have suggested that the PNN facilitates …