The roles of perineuronal nets and the perinodal extracellular matrix in neuronal function

JW Fawcett, T Oohashi, T Pizzorusso - Nature Reviews Neuroscience, 2019 - nature.com
Perineuronal nets (PNNs) are extracellular matrix (ECM) chondroitin sulfate proteoglycan (CSPG)-containing
structures that surround the soma and dendrites of various mammalian …

Diverse functions of perineuronal nets

M Karetko, J Skangiel-Kramska - Acta neurobiologiae experimentalis, 2009 - ane.pl
Perineuronal nets may play a beneficial … neurons and protecting them from the influence
of harmful agents. On the other hand, perineuronal nets create a barrier which limits neuronal

Perineuronal nets: subtle structures with large implications

H Carceller, Y Gramuntell, P Klimczak… - The …, 2023 - journals.sagepub.com
Perineuronal nets (PNNs) are specialized structures of the extracellular matrix that
surround the soma and proximal dendrites of certain neurons in the central nervous system, …

Casting a wide net: role of perineuronal nets in neural plasticity

BA Sorg, S Berretta, JM Blacktop… - Journal of …, 2016 - Soc Neuroscience
Perineuronal nets (PNNs) are unique extracellular matrix structures that wrap around
certain neurons in the CNS during development and control plasticity in the adult CNS. They …

The perineuronal net and the control of CNS plasticity

D Wang, J Fawcett - Cell and tissue research, 2012 - Springer
Perineuronal nets (PNNs) are reticular structures that surround the cell body of many … and
important functions that it may be performing. The involvement of PNNs in neuronal plasticity …

Perineuronal nets in brain physiology and disease

D Testa, A Prochiantz, AA Di Nardo - Seminars in cell & developmental …, 2019 - Elsevier
neural interstitials of brain parenchyma while condensed matrix called perineuronal nets (PNNs)
forms around a subset of neurons… PV cells), which are highly active neurons that need a …

[HTML][HTML] The perineuronal 'safety'net? Perineuronal net abnormalities in neurological disorders

TH Wen, DK Binder, IM Ethell… - Frontiers in molecular …, 2018 - frontiersin.org
Perineuronal nets may play a major role in PV neuron susceptibility and altered cortical
processing in presbycusis. The number of PNN expressing cells is reduced in aging mouse …

[HTML][HTML] Perineuronal nets and their role in synaptic homeostasis

M Bosiacki, M Gąssowska-Dobrowolska… - International journal of …, 2019 - mdpi.com
neuronal functionfunctioning of the blood-brain barrier, neuronal communication, as well
as the participation of PNNs in synaptic plasticity and some clinical aspects of perineuronal net

Perineuronal nets: plasticity, protection, and therapeutic potential

AC Reichelt, DJ Hare, TJ Bussey, LM Saksida - Trends in neurosciences, 2019 - cell.com
… The relationship between neurons and perineuronal nets (PNNs) is attracting attention
as a central mechanism controlling brain plasticity. In the cortex, PNNs primarily surround …

[HTML][HTML] An extracellular perspective on CNS maturation: perineuronal nets and the control of plasticity

D Carulli, J Verhaagen - International Journal of Molecular Sciences, 2021 - mdpi.com
Perineuronal nets are a condensed form of an extracellular matrix, which surrounds the … of
neurons, enwrapping synaptic terminals. Experimentally disrupting perineuronal nets in adult …