Perineuronal nets: subtle structures with large implications

H Carceller, Y Gramuntell, P Klimczak… - The …, 2023 - journals.sagepub.com
Perineuronal nets (PNNs) are specialized structures of the … Here we review the structure,
composition, and distribution of … approaches to study these structures. The function of PNNs …

Structural and functional modulation of perineuronal nets: in search of important players with highlight on tenascins

A Jakovljević, M Tucić, M Blažiková, A Korenić… - Cells, 2021 - mdpi.com
… technique and image analysis algorithm according to [126], in order to image PNN in the
hippocampus of TnC-deficient and wild-type mice after rearing in EE, we revealed subtle

Perineuronal nets in brain physiology and disease

D Testa, A Prochiantz, AA Di Nardo - Seminars in cell & developmental …, 2019 - Elsevier
… Owing to their unique structural organization, PNNs have … In this review, we define PNN
structure in detail and describe its … Thus, subtle changes or removal of PNNs can enhance local …

Neurons associated with aggrecan-based perineuronal nets are protected against tau pathology in subcortical regions in Alzheimer's disease

M Morawski, G Brückner, C Jäger, G Seeger, T Arendt - Neuroscience, 2010 - Elsevier
The biological basis for the selective vulnerability of neurons in Alzheimer's disease (AD) is
elusive. Aggrecan-based perineuronal nets (PNs) of the extracellular matrix have been …

A sweet talk: the molecular systems of perineuronal nets in controlling neuronal communication

HM Van't Spijker, JCF Kwok - Frontiers in integrative neuroscience, 2017 - frontiersin.org
Perineuronal nets (PNNs) are mesh-like structures, … Axonal sprouting is a form of structural
neuronal plasticity, the axon … can increase our capacity to subtly interfere with the PNNs to …

Structural changes in perineuronal nets and their perforating GABAergic synapses precede motor coordination recovery post stroke

E Dzyubenko, KI Willig, D Yin, M Sardari… - Journal of Biomedical …, 2023 - Springer
… Here we explored how perineuronal nets (PNNs), the facet-like ECM layers surrounding
fast-spiking interneurons, contribute to neurological recovery after focal cerebral ischemia in …

[HTML][HTML] Topological remodeling of cortical perineuronal nets in focal cerebral ischemia and mild hypoperfusion

E Dzyubenko, D Manrique-Castano, C Kleinschnitz… - Matrix Biology, 2018 - Elsevier
… We hypothesize that the observed structural rearrangement of PNNs may support … This
evidence suggests that the subtle modulation, but not crude depletion of extracellular matrix may …

Morphological and Molecular Characteristics of Perineuronal Nets in the Human Prefrontal Cortex—A Possible Link to Microcircuitry Specialization

I Banovac, MV Prkačin, I Kirchbaum… - Molecular …, 2024 - Springer
… We defined such structures as ECM aggregates. Compared to PNNs, ECM aggregates had
… regions (Figure S4), we found subtle differences in the laminar expression of these markers. …

Coherence and cognition in the cortex: the fundamental role of parvalbumin, myelin, and the perineuronal net

EA Bucher, JM Collins, AE King, JC Vickers… - Brain Structure and …, 2021 - Springer
networks mature, they are physically and functionally stabilised by axonal myelination and
development of the extracellular matrix structure termed the perineuronal net. … revealed subtle

Modulation of semaphorin3A in perineuronal nets during structural plasticity in the adult cerebellum

D Carulli, S Foscarin, A Faralli, E Pajaj… - Molecular and Cellular …, 2013 - Elsevier
… extracellular matrix structures, called perineuronal nets (PNNs)… is modified in parallel with
structural plasticity in the adult … of conditions associated with structural reorganization of the …