Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)

AC Bulua, A Simon, R Maddipati, M Pelletier… - Journal of Experimental …, 2011 - rupress.org
Reactive oxygen species (ROS) have an established role in … Here, we find that ROS
generated by mitochondrial … necrosis factor receptor-associated periodic syndrome (TRAPS), an …

Mitochondrial reactive oxygen species and inflammation: Molecular mechanisms, diseases and promising therapies

A Rimessi, M Previati, F Nigro, MR Wieckowski… - The international journal …, 2016 - Elsevier
… Using MitoQ, inflammatory cytokine production was abolished following LPS stimulation
in cells from patients with TNF receptor-associated periodic syndrome, an autoinflammatory …

Involvement of X-box binding protein 1 and reactive oxygen species pathways in the pathogenesis of tumour necrosis factor receptor-associated periodic syndrome

LJ Dickie, AM Aziz, S Savic, OM Lucherini… - Annals of the …, 2012 - ard.bmj.com
… N-terminal kinase (JNK) and p38 mitogen-activated protein kinases (MAPK),15 and
mitochondrial reactive oxygen species (ROS) controlling pro-inflammatory cytokine production.16 …

[PDF][PDF] Physiological roles of mitochondrial reactive oxygen species

LA Sena, NS Chandel - Molecular cell, 2012 - cell.com
… Historically, mitochondrial reactive oxygen species (mROS) … Introduction Reactive oxygen
species (ROS) are now appreciated to … The idea that a mitochondrial protein that participates in …

Mitochondria and reactive oxygen species

F Addabbo, M Montagnani, MS Goligorsky - Hypertension, 2009 - Am Heart Assoc
… “exothermic oxygen combustion and free radical emission.” This review is focused on one
… of the noxious mitochondrial pathway: reactive oxygen species (ROS) from a mitochondrial

Physiological functions of mitochondrial reactive oxygen species

TG Choi, SS Kim - Free Radic. Med. Biol, 2019 - books.google.com
… Innate immune response enhancement in patients with TNF receptor-associated periodic
syndrome (TRAPS) that is an autoinflammatory disorder is affected by missense mutations in …

Mitochondrial reactive oxygen species and risk of atherosclerosis

M Hulsmans, E Van Dooren, P Holvoet - Current atherosclerosis reports, 2012 - Springer
… Mechanisms that lead to increased mitochondrial reactive oxygen species (mtROS) production.
Because the overall mtROS levels are determined by the rates of ROS generation and …

Mitochondrial reactive oxygen species drive proinflammatory cytokine production

E Naik, VM Dixit - Journal of Experimental Medicine, 2011 - rupress.org
High levels of reactive oxygen species (ROS) are observed in chronic human diseases
such as neurodegeneration, Crohn’s disease, and cancer. In addition to the presence of …

Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release

DB Zorov, M Juhaszova, SJ Sollott - Physiological reviews, 2014 - journals.physiology.org
… Byproducts of normal mitochondrial metabolism and homeostasis … of reactive oxygen
species (ROS), Ca 2+ , etc., which must be normalized. Evidence suggests that brief mitochondrial

Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers

X Li, P Fang, J Mai, ET Choi, H Wang… - Journal of hematology & …, 2013 - Springer
reactive oxygen species (ROS) in the cell. As a major site of ROS production, mitochondria
have drawn considerable interest because it was recently discovered that mitochondrial ROS …