Mouse hematopoietic cell–targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging–like phenotype

C Mantel, S Messina-Graham, A Moh… - Blood, The Journal …, 2012 - ashpublications.org
… −/− animals is lengthened by treatment with a reactive oxygen species scavenger, which …
Reactive oxygen species (ROS) can activate the JAK/STAT pathway. JAKs are nonreceptor …

[图书][B] Autoinflammation in the TNF Receptor-Associated Periodic Syndrome (TRAPS): Pathophysiology and Implications for Treatment

AC Bulua - 2011 - search.proquest.com
Mitochondrial reactive oxygen species promote production of pro]inflammatory cytokines
and are elevated in TNFR1]Associated Periodic Syndrome (TRAPS). J Exp Med, 2011. 208 (3): …

[HTML][HTML] Cardiolipin deficiency affects respiratory chain function and organization in an induced pluripotent stem cell model of Barth syndrome

J Dudek, IF Cheng, M Balleininger, FM Vaz… - Stem cell …, 2013 - Elsevier
… on mitochondrial oxidative phosphorylation. We found an impaired remodeling of cardiolipin,
a dramatic decrease in basal oxygen … in generation of reactive oxygen species. Our data …

Mitochondrial dysfunction increases allergic airway inflammation

L Aguilera-Aguirre, A Bacsi… - The Journal of …, 2009 - journals.aai.org
reactive oxygen species (ROS) and induce mitochondrial dysfunction in the airway epithelium.
In this study, we investigated the involvement of preexisting mitochondrialmitochondrial

Intraplatelet reactive oxygen species, mitochondrial damage and platelet apoptosis augment non-surgical bleeding in heart failure patients supported by continuous …

NK Mondal, EN Sorensen, NJ Hiivala, ED Feller… - Platelets, 2015 - Taylor & Francis
… The aim of this study was to examine the role of intraplatelet reactive oxygen species (ROS)
and platelet damage on the incidence of bleeding events after CF-LVAD implantation in HF …

Systemic and cellular responses to intermittent hypoxia: evidence for oxidative stress and mitochondrial dysfunction

Y Peng, G Yuan, JL Overholt, GK Kumar… - … : From Cellular Signaling …, 2003 - Springer
Episodic hypoxia is associated with recurrent apnea syndromes (central or obstructive
apneas). Epidemiological studies have shown good correlation between apneas and …

Contribution of endogenously produced reactive oxygen species to the activation of podocyte NLRP3 inflammasomes in hyperhomocysteinemia

JM Abais, M Xia, G Li, TWB Gehr, KM Boini… - Free Radical Biology and …, 2014 - Elsevier
… However, it remains unknown which reactive oxygen species (ROS) are responsible for
this activation of NLRP3 inflammasomes and how such action of ROS is controlled. This study …

[HTML][HTML] Reactive oxygen species in macrophages: sources and targets

M Canton, R Sánchez-Rodríguez, I Spera… - Frontiers in …, 2021 - frontiersin.org
Reactive oxygen species (ROS) are fundamental for … However, growing evidence highlights
mitochondria as a crucial … of mitochondrial as compared to non-mitochondrial ROS sources. …

[HTML][HTML] Mitochondrial dysfunction and biogenesis: do ICU patients die from mitochondrial failure?

AV Kozlov, S Bahrami, E Calzia, P Dungel, L Gille… - Annals of intensive …, 2011 - Springer
… Besides ATP synthesis, the best-known function of mitochondria, they are involved in … most
important mitochondrial activities are oxidative phosphorylation and reactive oxygen species (…

Functional analysis of a novel G87V TNFRSF1A mutation in patients with TNF receptor-associated periodic syndrome

S Tsuji, H Matsuzaki, M Iseki, A Nagasu… - Clinical & …, 2019 - academic.oup.com
… Tumor necrosis factor (TNF) receptor-associated periodic syndrome (TRAPS) is an … and
T90I mutations showed increased mitochondrial reactive oxygen species (ROS). Furthermore, …