… concentrate on analgesic effects following the activation of peripheral opioid receptors on …
In summary, this chapter discussed developments in the field of peripheral opioid receptors, …

… naltrexone and peripheral opioid antagonist … effect on dural plasma protein extravasation
seems to be only centrally mediated. However, the interaction of BT-A with endogenous opioid …

… Peripheral opioid effects are not readily detectable in normal … the preexistence of opioid
receptors on peripheral-nerve … of opioid-receptor mRNA in dorsal-root ganglia 7 and opioid-…

… In human clinical trials and rat models of inflammatory pain, peripherally restricted opioids
have repeatedly shown powerful analgesic effects; in some mouse models however, their …

… effects, the potential that opioid receptors of the peripheral … the activation of peripheral
opioid receptors include the … doses of opioids, and the use of hydrophilic opioids that do not …

… In order to ensure that opioid effects on CGRP release from the nerve were congruent with
modulation at the peripheral terminals themselves, we also tested the effects of deltorphin (…

… These discrepancies might be related to the different study settings, but taken altogether, in
our opinion, these observations indicated that peripheral opioid system seems to be involved …

… The above disparities may be explained by the finding that peripheral opioids have no effect
if the perineurial barrier is intact, but do if the perineurium is permeable [1]. Breeching the …

… while avoiding the bothersome-to-dangerous centrally mediated adverse effects of centrally
acting opioids. Molecules known for their central action (eg, morphine) have been used in …

… terminals of primary afferents, we chose to study the analgesic effects of opioids on PGE,-induced
hyperalgesia. We observed that the intradermal co-injection of the mu-…