… of peripheral opioid receptors [1,2,4,40,41]. In these studies, alvimopan was found to prevent
opioid … subjects without antagonizing central opioid effects, such as analgesia and pupillary …

… To investigate the role of peripheral opioid receptors in the antinociceptive effect of systemically
administered μ agonists under normal conditions and during σ 1 inhibition, we tested the …

… effects of κ-ORAs summarized above occur at a opioid-like receptor in the periphery that is
different from the κ-opioid … on the basis of the clustered dose-effect functions and the ability of …

… effect was expected. Taken together, our results strongly suggest that EA induces peripheral
opioid release and activates peripheral opioid … effect of acupuncture and peripheral opioid …

… effects of sigma-1 antagonism during inflammation. In conclusion, sigma-1 receptors curtail
immune-driven peripheral opioid … the analgesic effects induced by drugs without opioid action…

… In this study, we found that tolerance develops to the peripheral antinociceptive effects of
DAMGO and CPA after repeated administration of these agents in the hindpaw of the rat. Since …

… Along with their peripheral analgesic effect new morphiceptin analogs inhibited
gastrointestinal transit in vivo making them interesting novel therapeutics in the treatment of …

… it is not known if these peripheral receptors contribute to the analgesic activity of opiates and
opioid peptides. Recently, peripheral analgesic effects of opiates have been evaluated after …

… opioid effects outside the eNS, including those arising locally in the gut. In addition, newer
peripheral … effects, as has already been done successfully in animal models (12, 47,89, 152). …

… peripheral opioid receptor, methylnaltrexone may help elucidate the mechanisms of action
of peripheral opioid effects … may help ameliorate other opioid side effects such as urinary …