… ) and RING (Pex2p, Pex10p, Pex12p) peroxins and is also implicated in cargo release of
PTS1 … Diagram shows domain map of Pex5p. Boxes represent TPR domains. (B) PpPex8p …

… , PEX19 and PEX16. PMPs can sort directly to peroxisomes or indirectly via the ER. In the
direct pathway PEX19 … The Pex11 protein family (all show as PEX11) and the fungal peroxins …

… peroxins Pex19 and Pex3, are thought to be the key elements of PMP trafficking in cells 18 .
While Pex19 … Deletion of one of these peroxins results in cells devoid of mature peroxisomes…

… peroxins are constituents of the peroxisomal membrane and contain cytosolically exposed
domains … Saccharomyces cerevisiae Pex3p and Pex19p are required for proper localization …

… and characterized the peroxin Pex19p of the yeast Y. lipolytica. Pex19p is not required for
the assembly of the peroxisomal membrane in Y. lipolytica, because pex19 mutants of this …

… with PEX13, which is in line with our data using artificial fragments for domain mapping. …
formation with peroxins. PEX26Δex5 interacts with its Cterminal domain (HR2) with PEX19 in the …

… topological domains of other PMPs that interact with Pex19p, … a peroxin may be physically
separated from each other, or they may represent different conformational states of the peroxin…

… PEX19 which can be achieved by addition of charged amino acids. Increasing charge further,
resulting in high affinity for PEX19 … -evolved, binding to PEX19 may have been a selective …

… in a Pex19p-dependent manner. In contrast, ABCD4 is targeted to lysosomes via the ER since
ABCD4 lacks a domain for the interaction of Pex19p, … Three peroxins, Pex3p, Pex19p, and …

… Since our last review in 2018, the number of identified peroxins has further increased to 39
(… peroxin, PEX38, has been identified in Trypanosoma brucei as a binding partner of PEX19. …