… neuroinflammation in response to TBI may play a fundamental role. This study aimed to
determine whether progranulin (… PGRN-deficient and wild-type mice were subjected to controlled …

… In light of this, it is not surprising that wounds in SLPI deficient mice have increased … by
elastase in wounds of SLPI-deficient mice. Deficiency in SLPI has the potential to disrupt the ratio …

… Persistence of the infection was associated with a more sustained … -deficient brain To
determine if there is any sign of dysregulated inflammation in the brains of PGRN-deficient mice, we …

… in chronic inflammatory conditions such as rheumatoid arthritis [13], osteoarthritis [14], and
inflammatory bowel disease [15], as well as acute inflammation … aggravate neuroinflammatory …

… deficiency causes progressive neurodegeneration through enhanced microglia activation and
chronic inflammation … their neurotoxic capability might prevail in chronic conditions [21, 22]…

… therapeutic options for raising progranulin levels to treat progranulin-deficient FTD, as well
… Dysregulation of progranulin-mediated cell growth and inflammation may be involved in the …

… cause of permanent blindness among elderly individuals worldwide. Chronic inflammation
in … Progranulin (PGRN) is a growth factor secreted from myeloid cells and plays an important …

… Progranulin-deficient primary microglia showed an altered cytokine profile in response to
LPS stimulation in culture. Progranulin-deficient … function and chronic neuroinflammation may …

… In AD, the chronic Aβ accumulation causes cerebral neuroinflammation by activating microglia
[35]. PGRN expression has been shown to correlate with dense-core plaques [58], and is …

… PGRN on microglial inflammation and neurodegeneration will be … with many acute and
chronic inflammatory conditions, … deficiency reduced the spatial learning acquisition deficit at …