… ) therapy, antibody-drug conjugates (ADCs) therapy, and chimeric antigen receptor T cells
(CAR-T cells) therapy … , and how to improve clinical outcomes persists obscure. In this review, …

… obstacles to the clinical efficacy of stem cell-based therapies. For example, stem cell therapy
is mentioned frequently in conjunction with type 1 diabetes, though its therapeutic potential …

… on traditional gene therapy delivery systems. In this review, we present siRNA delivery
method strategies and discuss the potential of RNAi‐based gene therapy in cancer treatment. (…

… persisting despite standard aggressive therapy. … therapy, which might become an improved
therapeutic approach in the future. These improvements may foster the therapeutic potential …

… is widely recognized as one of the major obstacles to achieving eradication of virus [43,44]
, low levels of HIV replication may persist in infected individuals despite their treatment with …

… Despite these admirable accomplishments, many endemic countries still face enormous
obstacles on the road to malaria eradication. The vast majority (85%) were in Africa, inflicting …

Gene therapy is a promising tool for the treatment of human diseases that cannot be cured by
rational therapies. The major limitation for the use of small interfering RNA (siRNA), both in …

… This review focuses on discussion of the obstacles that oncolytic virotherapy faces and
recent advances made to overcome them, with particular reference to adenoviruses. …

… The potential use of hiPSCs and organoids for clinical transplantation has increased … and
feasibility persist.32 Some obstacles related to general feasibility of “stem cell therapies” are …

… as dictate response to cancer therapy. Despite the significant obstacles that tumor-reactive
T … Second, if tumors persist, chronic TCR signaling can lead to a T cell-intrinsic program of …