[HTML][HTML] The dilemmas and possible solutions for CAR-T cell therapy application in solid tumors
L Wang, L Zhang, LC Dunmall, YY Wang, Z Fan… - Cancer Letters, 2024 - Elsevier
… obstacle to the therapeutic drugs, but also affects the metabolic state within the TME that
impacts therapeutic … Excessive costimulatory signaling may also reduce the persistence of CAR-…
impacts therapeutic … Excessive costimulatory signaling may also reduce the persistence of CAR-…
[HTML][HTML] Therapeutic potential of exploiting autophagy cascade against coronavirus infection
… , a number of potential therapeutic approaches against SARS… aim of finding potential targets
for therapeutic interventions in … about such studies and potential therapeutic interventions of …
for therapeutic interventions in … about such studies and potential therapeutic interventions of …
[HTML][HTML] Obstacles for T-lymphocytes in the tumour microenvironment: Therapeutic challenges, advances and opportunities beyond immune checkpoint
NK Verma, BHS Wong, ZS Poh, A Udayakumar… - …, 2022 - thelancet.com
… the complex TME obstacles for tumour-infiltrating T-lymphocytes, aiming to stimulate further
research for developing new therapeutic strategies by harnessing the full potential of the …
research for developing new therapeutic strategies by harnessing the full potential of the …
[HTML][HTML] HIV reservoirs as obstacles and opportunities for an HIV cure
… The persistence of HIV reservoirs remains a formidable obstacle to achieving sustained
virologic remission in HIV-infected individuals after antiretroviral therapy (… on their persistence is …
virologic remission in HIV-infected individuals after antiretroviral therapy (… on their persistence is …
Latent reservoirs of HIV: obstacles to the eradication of virus
… an infected individual is the persistence of latently infected, resting … which virus could be
isolated persists in essentially all infected … , and the mechanisms of its persistence, as well as in …
isolated persists in essentially all infected … , and the mechanisms of its persistence, as well as in …
[HTML][HTML] Therapeutic potential of autophagy modulation in cholangiocarcinoma
H Perez-Montoyo - Cells, 2020 - mdpi.com
… Even though the molecular mechanisms of autophagy regulation of tumor biology are not
fully understood, multiple reports are showing promising therapeutic potential in combination …
fully understood, multiple reports are showing promising therapeutic potential in combination …
[HTML][HTML] CAR T cell therapy of non-hematopoietic malignancies: detours on the road to clinical success
KB Long, RM Young, AC Boesteanu… - Frontiers in …, 2018 - frontiersin.org
… therapy for solid tumors, potential T cell-intrinsic determinants of response and resistance as
well as extrinsic obstacles … in vivo expansion and persistence of the transferred lymphocytes…
well as extrinsic obstacles … in vivo expansion and persistence of the transferred lymphocytes…
Concise review: mesenchymal stem (stromal) cells: biology and preclinical evidence for therapeutic potential for organ dysfunction following trauma or sepsis
… The second wave is characterized by progressive neuronal death, prolonged inflammation,
blood brain and Central Nervous System (CNS) barrier compromise, edema, and persisting …
blood brain and Central Nervous System (CNS) barrier compromise, edema, and persisting …
[HTML][HTML] “Persisters”: survival at the cellular level
CC Dawson, C Intapa, MA Jabra-Rizk - PLoS pathogens, 2011 - journals.plos.org
… obstacle for the treatment of infectious diseases, persistence has … But the mechanisms of
bacterial persistence are becoming … phenomenon of survival and persistence in cells as diverse …
bacterial persistence are becoming … phenomenon of survival and persistence in cells as diverse …
[HTML][HTML] Mesenchymal stromal cell therapeutic delivery: translational challenges to clinical application
… extensively studied for their therapeutic potential across a wide … , and potential safety concerns
associated with MSC therapy … Studies on MSC persistence in vivo have shown prolonged …
associated with MSC therapy … Studies on MSC persistence in vivo have shown prolonged …