… The most frequent complication of topical scabicides is persisting post-scabies eczema (generalized
eczematous dermatitis) from the various formulations. Further, it may be difficult to …

… This latter property of siRNAs carries an immense therapeutic potential. Cellular genes …
Other viral vectors based upon AAV and adenovirus do not stably integrate, but persist as …

… to CAR-T cell therapy is poor T cell expansion and short-term T cell persistence. It has been
… However, obstacles still remain, which were discussed in this review. Training a workforce …

… Nanoparticulate DDSs hold great potential to overcome the obstacles to efficiently target a
number of diverse cell types. The small size, customized surface, improved solubility, and multi…

… Here we provide proof-of-principle for the therapeutic potential of the WX8-family of …
induced by WX8 provide enhanced therapeutic potential over drugs that disrupt autophagy at a …

… In this paper, the potential advantages of, and obstacles to, successful systemic delivery
of … Clearly, in order for this method to be effective, the virus must persist in the circulation …

… Despite some evidence to the contrary 15,16 , ongoing viral replication has been suggested
to contribute to the persistence of HIV-1 infection even in the presence of therapy. Sensitive …

… of new antimicrobials either as a single therapy or as a combination therapy as D-Ctl also
has the … As a consequence, there is a persisting and urgent medical need to develop new …

… Moreover, the complexity and persistence of the chronic wound bed suggest that delivery of
a single entity as a corrective therapeutic may not be sufficient. A combination and/or patient-…

… The foremost damaging effect of reperfusion is the generation of ROS via mitochondria, which
are responsible for acute injury to cells, persisting for weeks without any intervention. ROS …