The causes of evolvability and their evolution
… fundamental: evolvability is the ability of a biological system to produce phenotypic variation
that is … , synergistic epistasis is also used to describe negative epistasis among deleterious …
that is … , synergistic epistasis is also used to describe negative epistasis among deleterious …
An evolutionary perspective on epistasis and the missing heritability
… two-locus patterns; Figure S1) and assuming that the phenotype had a direct effect on fitness
we calculated their expected allele frequency trajectories over time. With these outcomes …
we calculated their expected allele frequency trajectories over time. With these outcomes …
Genotype networks of 80 quantitative Arabidopsis thaliana phenotypes reveal phenotypic evolvability despite pervasive epistasis
G Schweizer, A Wagner - PLoS computational biology, 2020 - journals.plos.org
… We report pervasive epistasis in these genotype networks. Even though such epistasis can
… study the influence of epistasis on the evolvability of whole-organism phenotypes, we chose P…
… study the influence of epistasis on the evolvability of whole-organism phenotypes, we chose P…
Epistasis in protein evolution
TN Starr, JW Thornton - Protein science, 2016 - Wiley Online Library
… pervasive epistasis in which the physical and biological effects of mutations change over
the course of evolution … effects on these phenotypes, so negative epistasis in the majority of …
the course of evolution … effects on these phenotypes, so negative epistasis in the majority of …
Pervasive epistasis exposes intramolecular networks in adaptive enzyme evolution
… of epistasis in enzyme evolution by analyzing 41 fitness landscapes generated from seven
enzymes. We show that >94% of all mutational and epistatic … changes in epistasis along …
enzymes. We show that >94% of all mutational and epistatic … changes in epistasis along …
The causes of epistasis
JAGM De Visser, TF Cooper… - Proceedings of the …, 2011 - royalsocietypublishing.org
… study epistasis to understand the genotype–phenotype map, … , although not ubiquitous, is
quite common and sometimes … of epistasis, we do not yet understand how evolution shapes …
quite common and sometimes … of epistasis, we do not yet understand how evolution shapes …
The role of epistatic gene interactions in the response to selection and the evolution of evolvability
… architecture of the genotype–phenotype map determines evolvability, but few studies have
… we use the multilinear epistatic model to study the effects of different forms of epistasis on the …
… we use the multilinear epistatic model to study the effects of different forms of epistasis on the …
[PDF][PDF] The genotype-phenotype map structure and its role for evolvability
… the notions of pleiotropy and epistasis, and argue that their effect on evolvability is not captured
… With re spect to biological traits, then, pleiotropy is ubiquitous but not universal, so each …
… With re spect to biological traits, then, pleiotropy is ubiquitous but not universal, so each …
Global epistasis makes adaptation predictable despite sequence-level stochasticity
… Epistatic interactions between mutations are pervasive in microbial … of epistasis (8–10), which
can drive convergent phenotypic … laboratory evolution experiment in S. cerevisiae (fig. S1). …
can drive convergent phenotypic … laboratory evolution experiment in S. cerevisiae (fig. S1). …
Rates of fitness decline and rebound suggest pervasive epistasis
… The simplest model pictures evolution as a walk in a geometric space of n phenotypic traits.
It assumes that, within a given constant environment, a single value for each of the n traits is …
It assumes that, within a given constant environment, a single value for each of the n traits is …
相关搜索
- enzyme evolution pervasive epistasis
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- epistasis in protein evolution
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- intramolecular networks pervasive epistasis
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- genotype networks pervasive epistasis