… Thus, in this study, we propose that overexpression of Sesn2 in the spinal cord may
alleviate OA pain through modulation of AMPK/PGC-1α-mediated mitochondrial biogenesis. …

… The decrease in intracellular levels of both glutamine and glutamate under SESN2-down-regulated
conditions and their increase post-SESN2 overexpression indicated that Sestrin2 did …

… PGC-1α activation or overexpression could be used to compensate for neuronal … involve
PGC-1α 11 . In addition, researchers have found that mRNA and protein levels of PGC-1α were …

… The decrease in intracellular levels of both glutamine and glutamate under SESN2down-regulated
conditions and their increase postSESN2 overexpression indicated that Sestrin2 did …

… Knockout or silencing of Sestrin2 (Sesn2) resulted in imbalanced mitochondrial fusion and
… , which was attenuated by aerobic exercise or overexpression of Sesn2. Moreover, we found …

… Furthermore, overexpression of PGC-1α in transgenic mice and pigs increased the proportion
of red/oxidative type I fiber, accompanied by elevated levels of oxidative fiber markers …

… However, we found that Sestrin2 overexpression unexpectedly increased fat accumulation,
… To investigate the metabolic consequences of Sestrin2 overexpression, we engineered …

… Consistently, Sestrin2 overexpression hinders foam cell formation and … Sestrin2 causing
TGF-β-mediated liver fibrosis to deteriorate (Figure 3) [141]. Similarly, Sestrin2 overexpression …

… In a recent study, we found that Sestrin2 overexpression in brown adipocytes interfered
with normal metabolism by reducing mitochondrial respiration through the suppression of …

… Sestrin2 (SESN2) is a well described regulator of autophagy and antioxidant responses
and has been gaining attention due to its role in aging-associated pathologies and redox …