Microenvironmental pH-modification to improve dissolution behavior and oral absorption for drugs with pH-dependent solubility

C Taniguchi, Y Kawabata, K Wada… - Expert opinion on …, 2014 - Taylor & Francis
… : For the pH-modification approach, the microenvironmental pH at the diffusion area can be
altered by dissolving pH-modifyingpH could improve dissolution behavior of drugs with pH-…

Improving dissolution behavior and oral absorption of drugs with pH-dependent solubility using ph modifiers: a physiologically realistic mass transport analysis

N Salehi, G Kuminek, J Al-Gousous… - Molecular …, 2021 - ACS Publications
… In this study, we investigated the addition of pH-modifying excipients to IR weak base
formulations administered under high gastric pH, simulating the co-administration of formulation …

Influence of pH, particle size and crystal form on dissolution behaviour of engineered nanomaterials

ML Avramescu, PE Rasmussen, M Chénier… - … Science and Pollution …, 2017 - Springer
dissolution of ENMs at body temperature (37 C) using two pH conditions (1.5 and 7) to
approximately frame the pH … form and pH on dissolution behaviour of the investigated materials. …

… vivo absorption behavior of oral modified release dosage forms containing pH-dependent poorly soluble drugs using a novel pH-adjusted biphasic in vitro dissolution …

U Heigoldt, F Sommer, R Daniels… - European journal of …, 2010 - Elsevier
… 17, indicated that dissolution testing using the biphasic … behavior and bioavailability of
modified release formulations compared to conventional dissolution testing at pH 1, pH 5.5, or pH

Dissolution-modulating mechanism of pH modifiers in solid dispersion containing weakly acidic or basic drugs with poor water solubility

PHL Tran, TTD Tran, KH Lee, DJ Kim… - Expert opinion on drug …, 2010 - Taylor & Francis
… Actually, pH M control of the dissolution behaviors of water-insoluble drugs in SD systems
was applied widely a few decades ago. An internal buffer system comprising various disodium …

Improved dissolution and pharmacokinetic behavior of dipyridamole formulation with microenvironmental pH-modifier under hypochlorhydria

S Onoue, R Inoue, C Taniguchi, Y Kawabata… - International journal of …, 2012 - Elsevier
Dissolution behavior of dipyridamole formulations To evaluate possible enhancement of
dissolution behavior by microenvironmental pH-modifying approach, dissolution testing for DPG/…

Effect of micro-environment modification and polymer type on the in-vitro dissolution behavior and in-vivo performance of amorphous solid dispersions

W Sun, B Pan - European Journal of Pharmaceutical Sciences, 2017 - Elsevier
… This may cause inconsistent behavior between in-vitro and in-vivo systems (Onoue et al., …
pH modifier in relation to the bioavailability of the micro-environmental pH modifying SD (pH M -…

Surface modification and dissolution behavior of Mg–Al hydrotalcite particles

S Xu, MC Liao, HY Zeng, XJ Liu, JZ Du, PX Ding… - Journal of the Taiwan …, 2015 - Elsevier
Dissolution of the AHT at different constant pH To determine the dissolution behavior of the
AHT in aqueous solutions of different pH, the AHT dissolution experiments were conducted …

[HTML][HTML] Improved dissolution of dipyridamole with the combination of pH-modifier and solid dispersion technology

Y Kojo, S Matsunaga, H Suzuki, C Taniguchi… - Chemical and …, 2017 - jstage.jst.go.jp
… improving the dissolution behavior of DP … dissolution behavior of weak basic drugs under
intestinal conditions could be improved by pH-modifying technology, the dissolution behavior

Effects of acid and Na2SiO3 modification on the dissolution behavior of 2CaO· SiO2-3CaO· P2O5 solid solution in aqueous solutions

C Du, X Gao, S Kim, S Ueda, S Kitamura - ISIJ International, 2016 - jstage.jst.go.jp
… In this study, the effects of acid as leaching agent, high temperature modification of C 2 S–C
3 P by Na 2 SiO 3 , and pH on the dissolution behavior of C 2 S–C 3 P in aqueous solutions …