… may have important implications in the regulation of phagocytosis and virulence. The
type of phagocytic cells may also have an important role on the outcome of infection by C. …

… Interestingly, the Δapp1 mutant strain showed a decreased virulence in mice deficient for …
This study identifies App1 as a novel regulator of virulence for C. neoformans, and it …

… cells, including the antiphagocytic properties and how phagocytosis is achieved, and also, …
once the yeast is phagocytosed. Cryptococcus neoformans can avoid internalization by …

… Furthermore these facts underscore that every virulence factor needs to be viewed in the
context of the interaction. For example, the capsule is antiphagocytic in vitro but phagocytosis …

… Meningoencephalitis caused by Cryptococcus neoformans (Cn) has become one of the …
between Cn and phagocytes is fundamental in exploring the pathogenicity of cryptococcal …

… intrinsic virulence of clinical isolates of Cryptococcus neoformans … Patients with isolates that
had high phagocytic indices and … Conversely, patients with isolates exhibiting low phagocytic …

… phagocytic process was inhibited by cryptococcal … phagocytosis experiments with alveolar
macrophages. Our studies were conducted to determine whether these cells phagocytize C…

… Most studies about virulence have focused on Cryptococcus neoformans, and for this reason…
ability is very similar to the behavior during the interaction with mammalian phagocytic cells. …

… with the virulence of Cryptococcus neoformans. The capsule inhibits phagocytosis by …
It is our current view that phagocytosis of the yeast is dependent on a balance between the …

… capsule of the human fungal pathogen Cryptococcus neoformans is a major virulence
attribute. However, previous studies of the pleiotropic virulence determinant Gat201, a GATA …