An engineering study on the enhanced control and operation of continuous manufacturing of pharmaceutical tablets via roller compaction

R Singh, M Ierapetritou, R Ramachandran - International journal of …, 2012 - Elsevier
… In this manuscript an efficient control system for an integrated continuous pharmaceutical
tablet manufacturing process with roller compaction has been designed. The designed control

Development and implementation of an advanced model predictive control system into continuous pharmaceutical tablet compaction process

A Bhaskar, FN Barros, R Singh - International journal of pharmaceutics, 2017 - Elsevier
… leads to new ways of developing MPC models, tablet weight measurement methods and
control strategies that enhance the manufacturability and quality of pharmaceutical tablets. …

Implementation of an advanced hybrid MPC–PID control system using PAT tools into a direct compaction continuous pharmaceutical tablet manufacturing pilot plant

R Singh, A Sahay, KM Karry, F Muzzio… - International journal of …, 2014 - Elsevier
tablet manufacturing pilot plant and an NIR based PAT tool. The advanced hybrid MPC–PID
control scheme leads to enhanced controlcontrol scheme indicating its potential to improve …

Closed-loop feedback control of a continuous pharmaceutical tablet manufacturing process via wet granulation

R Singh, D Barrasso, A Chaudhury, M Sen… - … of Pharmaceutical …, 2014 - Springer
… In this study, an efficient control system for an integrated continuous pharmaceutical tablet
manufacturing process via wet granulation has been designed. The designed control system …

System-wide hybrid MPC–PID control of a continuous pharmaceutical tablet manufacturing process via direct compaction

R Singh, M Ierapetritou, R Ramachandran - European Journal of …, 2013 - Elsevier
… requirement of a hybrid control scheme such as a combined MPC–PID control scheme. In
this … hybrid control strategy for an integrated continuous pharmaceutical tablet manufacturing …

Advanced control of continuous pharmaceutical tablet manufacturing processes

R Singh, C Velazquez, A Sahay, KM Karry… - Process Simulation and …, 2016 - Springer
… There is no standard control package (commercially available) that can be employed to
implement a control system in a pharmaceutical plant. If pharmaceutical companies need to shift …

… enhancement of the solubility and dissolution of a class II BCS drug using polymeric surfactants and crystallization inhibitors: development of controlled-release tablets

EB Basalious, W El-Sebaie, O El-Gazayerly - Aaps Pharmscitech, 2011 - Springer
… ® 974 in controlling felodipine release from the CR tablet matrix. Our results proposed that
pharmaceutical QbD and DOE were successfully applied for enhancement of the solubility …

Implementation of control system into continuous pharmaceutical manufacturing pilot plant (powder to tablet)

R Singh - Computer Aided Chemical Engineering, 2018 - Elsevier
control system into continuous pharmaceutical tablet manufacturing process has been reviewed.
A systematic framework for the controlcontrol system into direct compaction continuous …

Sensitivity analysis of a pharmaceutical tablet production process from the control engineering perspective

J Rehrl, A Gruber, JG Khinast, M Horn - International journal of …, 2017 - Elsevier
… This paper presents a sensitivity analysis of a pharmaceuticalcontrol concept. Examining
its results in a systematic manner makes it possible to assign actuating signals to controlled

A perspective on Quality-by-Control (QbC) in pharmaceutical continuous manufacturing

Q Su, S Ganesh, M Moreno, Y Bommireddy… - Computers & Chemical …, 2019 - Elsevier
… , nor its validity in enhancing the real-time tablet weight control was confirmed. For … control
into the tablet quality attributes compared to the conventional open-loop or the Level 0 control