Population pharmacokinetics of piperacillin at two dose levels: influence of nonlinear pharmacokinetics on the pharmacodynamic profile

CB Landersdorfer, JB Bulitta… - Antimicrobial agents …, 2012 - Am Soc Microbiol
… Three recent population PK analyses favored models with … different piperacillin dose levels
that was analyzed by population PK modeling. Also, the impact of the saturation of piperacillin

First-dose and steady-state population pharmacokinetics and pharmacodynamics of piperacillin by continuous or intermittent dosing in critically ill patients with sepsis

JA Roberts, CMJ Kirkpatrick, MS Roberts… - International journal of …, 2010 - Elsevier
… known data examining the population pharmacokinetics of piperacillin in critically ill patients
… different pharmacokinetic parameters than those observed in other patient populations, …

Pharmacodynamic profiling of piperacillin in the presence of tazobactam in patients through the use of population pharmacokinetic models and Monte Carlo …

TP Lodise Jr, B Lomaestro, KA Rodvold… - Antimicrobial agents …, 2004 - Am Soc Microbiol
… were to describe the PK of piperacillin in the presence of tazobactam and to characterize
its pharmacodynamic profile. Through population PK modeling, the PK model that best …

Population pharmacokinetics of piperacillin in sepsis patients: should alternative dosing strategies be considered?

MG Andersen, A Thorsted, M Storgaard… - Antimicrobial agents …, 2018 - Am Soc Microbiol
PK profile for piperacillin given at 4 g every 8 h in 22 septic patients admitted to a medical
ward. Piperacillin … /liter), and the following PK/pharmacodynamic (PD) targets were evaluated: …

Population pharmacokinetics of piperacillin and tazobactam in critically ill patients undergoing continuous renal replacement therapy: application to pharmacokinetic …

E Asín-Prieto, A Rodríguez-Gascón… - Journal of …, 2014 - academic.oup.com
piperacillin and tazobactam pharmacokinetic parameters during critical illness and the lack
of population pharmacokinetic … a better understanding of piperacillin/tazobactam disposition …

Systematic comparison of the population pharmacokinetics and pharmacodynamics of piperacillin in cystic fibrosis patients and healthy volunteers

JB Bulitta, SB Duffull, M Kinzig-Schippers… - Antimicrobial agents …, 2007 - Am Soc Microbiol
PK in healthy volunteers in a controlled clinical study. Therefore, we compared the population
PK and pharmacodynamics (PD) of piperacillin … ) who each received 4 g piperacillin as a 5-…

Population pharmacokinetics and pharmacodynamics of piperacillin/tazobactam in patients with complicated intra-abdominal infection

C Li, JL Kuti, CH Nightingale… - Journal of …, 2005 - academic.oup.com
… The protein bindings of piperacillin and tazobactam in … MIC and result in pharmacodynamic
and pharmacoeconomic … to explore the population pharmacokinetics of piperacillin and …

Population pharmacokinetics and pharmacodynamics of extended-infusion piperacillin and tazobactam in critically ill children

K Nichols, EK Chung, CA Knoderer… - Antimicrobial agents …, 2016 - Am Soc Microbiol
… concentration-time profiles for piperacillin and tazobactam … concentration-time profiles of
piperacillin and tazobactam for … this study to build the population pharmacokinetic model (n = 12)…

Population pharmacokinetics and pharmacodynamics of piperacillin in critically ill patients during the early phase of sepsis

W Sukarnjanaset, S Jaruratanasirikul… - … and Pharmacodynamics, 2019 - Springer
… This study aimed to characterize the population pharmacokinetics (PKs) of piperacillin and
… Forty-eight patients treated with piperacillin/tazobactam were recruited. Five blood samples …

Population pharmacokinetics and pharmacodynamics of piperacillin and tazobactam administered by prolonged infusion in obese and nonobese patients

EK Chung, SC Cheatham, MR Fleming… - The Journal of …, 2015 - Wiley Online Library
… of piperacillin/tazobactam in hospitalized obese and … -state population pharmacokinetics of
piperacillin and tazobactam, … evaluate the pharmacodynamics of piperacillin and tazobactam …