Improved dissolution and pharmacokinetic behavior of dipyridamole formulation with microenvironmental pH-modifier under hypochlorhydria
S Onoue, R Inoue, C Taniguchi, Y Kawabata… - International journal of …, 2012 - Elsevier
… about the pharmacokinetic behavior of the modified-release formulation of DP under
hypochlorhydric condition. The acidic pH-modifiers are commonly used to manipulate the pH in …
hypochlorhydric condition. The acidic pH-modifiers are commonly used to manipulate the pH in …
Microenvironmental pH-modification to improve dissolution behavior and oral absorption for drugs with pH-dependent solubility
C Taniguchi, Y Kawabata, K Wada… - Expert opinion on …, 2014 - Taylor & Francis
… microenvironmental pH. In addition, evaluating the release behavior of pH-modifiers from …
A better understanding of the pharmacokinetic and safety characteristics of nanoformulation …
A better understanding of the pharmacokinetic and safety characteristics of nanoformulation …
Amorphous solid dispersions of carvedilol along with pH‐modifiers improved pharmacokinetic properties under hypochlorhydoria
S Halder, A Tabata, Y Seto, H Sato… - … & Drug Disposition, 2018 - Wiley Online Library
… the improved dissolution and consistent pharmacokinetic behavior of CAR using ASD system
with pH-modifiers under hypochlorhydric conditions. The pH-modification technologies are …
with pH-modifiers under hypochlorhydric conditions. The pH-modification technologies are …
Novel formulations of dipyridamole with microenvironmental pH-modifiers for improved dissolution and bioavailability under hypochlorhydria
C Taniguchi, R Inoue, Y Kawabata, K Yamashita… - International journal of …, 2012 - Elsevier
… pH-modifier for solubilizing DP, possibly leading to improved pharmacokinetic behavior of
DP … Pharmacokinetic behavior of DP was evaluated after oral administration of DPG and DPG/…
DP … Pharmacokinetic behavior of DP was evaluated after oral administration of DPG and DPG/…
Improving dissolution behavior and oral absorption of drugs with pH-dependent solubility using ph modifiers: a physiologically realistic mass transport analysis
… This analysis also highlights a polyprotic pH modifier’s superiority to a monoprotic pH modifier
for drug compounds with high intrinsic solubility, high dose, and/or more basic pK a . It is …
for drug compounds with high intrinsic solubility, high dose, and/or more basic pK a . It is …
[HTML][HTML] Enhanced pharmacokinetic performance of dapoxetine hydrochloride via the formulation of instantly-dissolving buccal films with acidic pH modifier and …
HM Aldawsari, SM Badr-Eldin - Journal of Advanced Research, 2020 - Elsevier
… In addition, DPX pharmacokinetic behavior was studied after buccal administration of the
selected optimal formulation to rats in comparison to an oral reference product. …
selected optimal formulation to rats in comparison to an oral reference product. …
Improved dissolution and absorption of ketoconazole in the presence of organic acids as pH-modifiers
M Adachi, Y Hinatsu, K Kusamori, H Katsumi… - European Journal of …, 2015 - Elsevier
… as pH-modifiers. The purpose of this study is to (A) develop a solid oral formulation containing
KZ as a model compound and organic acids as pH-modifiers… a rat pharmacokinetic model. …
KZ as a model compound and organic acids as pH-modifiers… a rat pharmacokinetic model. …
Formulation of ondansetron HCl matrix tablets with microenvironmental pH modifier for improved dissolution and bioavailability under hypochlorhydria
A Anilkumar - Asian Journal of Pharmaceutics (AJP), 2016 - asiapharmaceutics.info
… pharmacokinetic behavior of ondansetron was studied. After oral administration of ondansetron
without pH modulating agent (F0) and with pH … compare the pharmacokinetic behavior of …
without pH modulating agent (F0) and with pH … compare the pharmacokinetic behavior of …
Microenvironmental pH-modified solid dispersions to enhance the dissolution and bioavailability of poorly water-soluble weakly basic GT0918, a developing anti …
M Yang, S He, Y Fan, Y Wang, Z Ge, L Shan… - International journal of …, 2014 - Elsevier
… The in vivo pharmacokinetics of the pH M -SDs tablets were also studied in beagle dogs …
modifiers affect the behavior of the drug in solid dosage forms by promoting the hydrophilic …
modifiers affect the behavior of the drug in solid dosage forms by promoting the hydrophilic …
Microenvironmental pH-modified Amisulpride-Labrasol matrix tablets: development, optimization and in vivo pharmacokinetic study
NF Younes, AEHI El Assasy, AIA Makhlouf - Drug Delivery and …, 2021 - Springer
… acidic pH modifier had similarity factor (f 2 ) ≥ 50 proving the pH independent release of AMS.
The pharmacokinetic … AMS imparted by the pH-modified matrix tablet containing Labrasol. …
The pharmacokinetic … AMS imparted by the pH-modified matrix tablet containing Labrasol. …
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