… Beta-lactam dose optimization in critical care is a current priority. We aimed to review the
pharmacokinetics (PK) of three commonly used beta-lactams … model to describe beta-lactam PK …

… infusion of /J-lactam antibiotics generally show continuous … Pharmacokinetic studies which
have been performed in … or, using population pharmacokinetic modelling, the elimination rate …

… @-lactam antibiotics in rats were investigated, and a physiologically based pharmacokinetic
model capable of … predicted by the model. These correlations demonstrate that the proposed …

… beta-lactams in a neutropenic mouse thigh infection model for both gram-positive and
gram-negative bacteria. In the same animal model, dosing regimens of beta-lactams … beta-lactam …

… of critically ill patients and beta-lactams are the most common … pharmacokinetics and
pharmacodynamics of beta-lactams. … the pharmacokinetics or pharmacodynamics of beta-lactam …

… based pharmacokinetic (PBPK) models consist of compartments representing different
tissues. As most models … This study aimed to assess the accuracy of PBPK-predicted beta-lactam …

… data from the neutropenic mouse thigh and lung models, as well as other animal models,
suggests that the ognize variation in pharmacokinetics between individuals. The calculation of …

… In addition to this, population pharmacokinetic models may anticipate treatment efficacy
in every patient, simulate different dosing regimens, and calculate PK/PD parameters (ie, fAUC) …

Introduction Several reports have shown marked heterogeneity of antibiotic pharmacokinetics
(PK) in patients admitted to ICUs, which might potentially affect outcomes. Therefore, the …

… beta-lactam antibiotics, using a PBPK model and to consider structural and statistical
modifications to the model to optimize the model … explore the influence of model parameters on the …