… Neutropenic mice are inoculated and treated with one of a wide range of dosage regimens
(varying dose and dosage interval) minimizing the interdependencies between the PD …

… dosing regimens. With phenytoin, which exhibits saturable metabolism, a small increase in
dose … active metabolites that would require more complicated therapeutic dosing regimens. …

… the start of the multiple dosing on day 4. Levofloxacin pharmacokinetics were linear and …
and intravenous dosing regimens, and the values of the pharmacokinetic parameters for the …

… difference (or lack thereof) in pharmacokinetics/pharmacodynamics. The purpose of this …
of dosage regimen and dosage form on the data analysis and interpretation of pharmacokinetic …

… A pharmacokinetic model simulating plasma concentrations expected to be achieved with a
fulvestrant loading dose (LD) regimen … the pharmacokinetics of the fulvestrant LD regimen. …

… a meropenem population pharmacokinetic model using patient data and use it to explore
alternative dosage regimens that could optimize the currently used dosing regimen to achieve …

… Under these circumstances, an estimate of the appropriate dosing regimen can be obtained
based on pharmacokinetic principles described in Chapter 1. Unless otherwise specified, …

… We report in this study safety and pharmacokinetic results of an alternative dosing regimen
for IVM. These results are of particular relevance for public health interventions based on …

… the AL regimens to include a dose that could support a 2-month (every 8 weeks [q8wk]) dose
interval may offer additional medication regimen … Extensive pharmacokinetic sampling was …

… frequency of dosing in this dosing regimen cannot … pharmacokinetic parameters between
D2 and D7, particularly inV and C max (14); hence, we determined the pharmacokinetic profiles …