… Variations in genes involved in drug disposition, and in … Pharmacogenomics involves the
search for genetic variations … 6986A>G, rs776746) in intron 3 as the most common variant, …

… common structural and functional properties [15-17,201]. More than 40 human ABC transporter
genes … [39] indicated that cells transduced with a variant with G2677T showed a reduced …

… Common polymorphisms of CYP 2C19 and CYP 2C9 after the pharmacokinetic and
pharmacodynamic … We also demonstrated that the pharmacokinetic parameters, AUC and C max …

… the stage for subsequent studies of genetic variations for other drug-metabolizing enzymes.
… The K variant is the most common variant at a frequency of 1%. On the other hand, the A, S …

… These variant alleles occur together in a common haplotype (MDR1*2), … genetic variants
and cytotoxic drug response have been presented in this paper. These genes and variations …

… Genetic variants in metformin transporters have been extensively studied as a likely … time,
the effect of genetic variants in transcription factors on metformin pharmacokinetics (PK) and …

… While there is a growing understanding of the genetic factors that contribute to the … genetic
variations in the response to antidiabetic drug therapies [3]. Type 2 diabetes is most commonly …

… of common genetic polymorphisms in transporter genes on the … In addition to pharmacokinetics,
a number of studies have … role of genetic variants in metformin pharmacodynamics and …

… screening prior to surgery to determine drug risk is not currently common practice (1). … on
the effects of genetic variations on the pharmacokinetics and pharmacodynamics of used drugs. …

… This review covers the effects of genetic variations in drug metabolizing enzymes, drug …
influence the pharmacokinetics and pharmacodynamics of some impactful or commonly used …