Medicinal chemistry and pharmacological effects of Farnesoid X Receptor (FXR) antagonists

C Lamers, M Schubert-Zsilavecz… - … in medicinal chemistry, 2014 - ingentaconnect.com
… in vitro, little is known about the pharmacological effects of FXR antagonists and so far only
… For an evaluation of the pharmacological in vivo effects and a potential therapeutic benefit …

Medicinal chemistry and molecular pharmacology of GABA-C receptors

GAR Johnston - Current topics in medicinal chemistry, 2002 - ingentaconnect.com
… The GABAC receptor concept arose from medicinal chemical … the unique physiology and
pharmacology of these relatively … on the medicinal chemistry and molecular pharmacology of …

The methylation effect in medicinal chemistry

EJ Barreiro, AE Kümmerle, CAM Fraga - Chemical reviews, 2011 - ACS Publications
… of the methyl group’s importance in molecular recognition, Wermuth wrote: 5 “The methyl
group, so often considered as chemically inert, is able to alter deeply the pharmacological

[图书][B] Medicinal chemistry: an introduction

G Thomas - 2011 - books.google.com
… This book is written for second and subsequent year undergraduates studying for degrees
in medicinal chemistry, pharmaceutical chemistry, pharmacy, pharmacology and other related …

HuR-targeted agents: an insight into medicinal chemistry, biophysical, computational studies and pharmacological effects on cancer models

G Assoni, V La Pietra, R Digilio, C Ciani… - Advanced Drug Delivery …, 2022 - Elsevier
The Human antigen R (HuR) protein is an RNA-binding protein, ubiquitously expressed in
human tissues, that orchestrates target RNA maturation and processing both in the nucleus …

Adenosine receptor antagonists: translating medicinal chemistry and pharmacology into clinical utility

PG Baraldi, MA Tabrizi, S Gessi, PA Borea - Chemical reviews, 2008 - ACS Publications
pharmacologicalmedicinal chemistry of these receptors have enabled researchers to identify
potential therapeutic areas for drug development. With the combination of pharmacological

Medicinal Chemistry of A3 Adenosine Receptor Modulators: Pharmacological Activities and Therapeutic Implications

PG Baraldi, D Preti, PA Borea… - … of medicinal chemistry, 2012 - ACS Publications
… (36) Although the exact nature of such cardioprotection mechanism would need further
investigation, it has been observed that the pharmacologic effect was reversed by a selective A 3 …

Medicinal chemistry, pharmacology, and clinical implications of TRPV1 receptor antagonists

M Aghazadeh Tabrizi, PG Baraldi… - Medicinal research …, 2017 - Wiley Online Library
… with interesting properties from a chemical and pharmacological point of view, showing in
… The medicinal chemistry section of this review summarizes new chemical entities of TRPV1 …

Chromatographic retention parameters in medicinal chemistry and molecular pharmacology

A Nasal, D Siluk, R Kaliszan - Current medicinal chemistry, 2003 - ingentaconnect.com
… At present, log P, as a measure of hydrophobicity, is still the most widely employed in
medicinal chemistry and molecular pharmacology. Large compilations of log P data have been …

Medicinal Chemistry, Pharmacology, and Potential Therapeutic Benefits of Cannabinoid CB2 Receptor Agonists

M Aghazadeh Tabrizi, PG Baraldi, PA Borea… - Chemical …, 2016 - ACS Publications
pharmacological effects of direct full or partial agonists and/or competitive antagonists. (35,
36) At present, no pharmacological or chemical … CB pharmacology could be hypothesized. …