The objective of the present paper was to evaluate the relevance of neuronal balance of
cyclic AMP and cyclic GMP concentration for functional regulation of nociceptor sensitivity …

… In addition, we illustrate how cGMP signaling becomes … cGMP plays in cardiac physiology
and pathophysiology presents great opportunities for pharmacologic modulation of the cGMP …

… ), or from pharmacologic agents, the nitrovasodilators. NO and cGMP together comprise an
especially wide-ranging signal transduction system when one considers (i) the many roles of …

… of cGMP regulates complex signaling cascades through immediate downstream effectors,
including cGMP-dependent protein kinases, cGMP-regulated phosphodiesterases, and …

… which cyclic GMP modulates cyclic AMP content. In the presence of endothelium, the increase
in cyclic GMP … in cyclic AMP levels thereby allows PDE IV (low VlKm ratio) to participate in …

… Cyclic GMP signaling pathway. Cyclic GMP is synthesized by soluble guanylate cyclases in
response to NO or by receptor guanylate cyclases, which are activated by natriuretic peptides…

… cyclic nucleotide machinery. Numerous complexes of ligands, enzymes, cofactors, and
substrates present significant targets for pharmacologic modulation … Cyclic GMP and cAMP may …

… by an L-arginine/nitric oxide/cyclic GMP cascade. Seven days after implantation of intrathecal
… -permeable cy-clic GMP analogs, dibutyryl cyclic GMP and 8-bromo cyclic GMP, produced …

… The activated sGC rapidly converts GTP into the second messenger 3‘,5‘-cyclic GMP (cGMP),
which, in turn, activates PKG. Through the activation of PKG, NO/cGMP signaling is …

… Although cyclic GMP was considered a potentially important second messenger in … role
for this cyclic nucleotide in signal transduction. The significance of cyclic GMP in cellular …