… Here, we discuss recent progress on the therapeutic potential of pharmacological and
nutritional modulators of autophagy, dissect the obstacles that have limited the development of …

… Similarly, discussion of the pharmacological modulation of signal transducers acting …
development of pharmacological agonists of nucleic acid-sensing TLRs faces several obstacles, as …

… Due to the lack of evidence for pharmacological options that act on descending … modulator
brain-derived neurotrophic factor.16, 17, 21, 22 In these circumstances if the stimuli persist, …

… for allosteric modulation of M 1 receptors in drug discovery for the treatment of neurocognitive
disorders, but at the same time, they also emphasize the significant challenges for …

… Several theories have been developed to explain compulsive drug use and relapse and,
while each of them has provided unique contributes, they converge on several important …

… lethal effects of a drug, is referred to as “persistence.” Persistence is distinct from resistance
… drug has been removed. Furthermore, upon retreatment, the recrudescent organisms are as …

… Given their role in the modulation of complex behaviors, we particularly believe that a
greater understanding of the interactions of neuropeptide signaling within brain reinforcement …

… allostery (allosteric modification of drug effect), effects along the … these apparently diverse
pharmacological effects in terms of … cause paradoxical drug classification and nomenclatures. …

Current medication for anxiety disorders is suboptimal in terms of efficiency and tolerability,
highlighting the need for improved drug treatments. In this review an overview of drugs being …

… Pharmacological modulation of autophagy has great therapeutic potential and attracted a
great deal of attention in the past two decades [18]. A variety of autophagy-focused databases …