Adenosine receptor signaling plays important roles in normal physiology, but is also known
to modulate the development or progression of several different diseases. The design of
new, efficient, and safe pharmacological approaches to target the adenosine system may
have considerable therapeutic potential, but is also associated with many challenges. This
review summarizes the main challenges of adenosine receptor targeted treatment including
tolerance, disease stage, cell type-specific effects, caffeine intake, adenosine level …