… , randomized, controlled trials with DTIC control arms for the … -blinded, randomized,
controlled, phase II trial to determine … efficacy in patients with stage IV metastatic melanoma; the …

… the present study was initiated in 2003 as a phase 2 multicenter randomized controlled trial
(… The logistics of conducting a rigorous clinical trial of a cell-based surgical intervention within …

… The aim of this study … randomly assigned to receive raltegravir (200 mg, 400 mg, or 600 mg)
or placebo orally twice daily in this multicentre, triple-blind, dose-ranging, randomised study. …

… -risk patients, including results from randomized clinical trials, meta-analyses, and Mendelian
randomization studies (3–6). However, the demonstration of incremental improvements in …

… In this phase 2, double-blind study, 124 subjects with biopsy-proven NASH were randomized
to once-daily placebo or 1, 5, 10, or 40 mg GS-9450 for 4 weeks. Absolute and percent …

… six phase 2 trials in a pooled analysis to determine the study design for phase 3 trials of … is
to present pooled data from randomized clinical trials at different study sites that evaluated the …

… studies. Phase II and phase III studies included in this analysis must have used identical …
In our sample, there were only two randomized phase II studies; therefore, inclusion of this …

… The VISION (VEGF Inhibition Study in Ocular Neovascularization) trials were the first
large-scale, multicenter, randomized controlled replicate trials to demonstrate that intravitreous …

… We used a novel clinical trial design in this study. … The design of this study represents a
novel approach to clinical trials in ALS, in terms of the lead-in and analysis as well as the efficacy …

… Design, Setting, and Participants This phase 2 randomized clinical trial compared erlotinib
… The trial was conducted in 17 US academic and community medical centers among 88 …