Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: a multicentre, randomised, placebo-controlled phase 3 study

F Cappuzzo, T Ciuleanu, L Stelmakh, S Cicenas… - The lancet …, 2010 - thelancet.com
… -kinase inhibitor erlotinib has … the phase 3, placebo-controlled Sequential Tarceva in
Unresectable NSCLC (SATURN; BO18192) study to assess use of erlotinib as maintenance therapy

A phase II trial of erlotinib as maintenance treatment after concurrent chemoradiotherapy in stage III non-small-cell lung cancer (NSCLC): a Galician Lung Cancer …

J Casal Rubio, JL Firvida-Perez… - Cancer chemotherapy …, 2014 - Springer
… agent erlotinib as maintenance therapy is an active treatment after cCRT in patients with stage
III NSCLC, … The safety profile of maintenance erlotinib was as expected and manageable. …

[HTML][HTML] A randomized phase III trial on maintenance treatment with bevacizumab alone or in combination with erlotinib after chemotherapy and bevacizumab in …

A Johnsson, H Hagman, JE Frödin, Å Berglund… - Annals of oncology, 2013 - Elsevier
erlotinib has shown to be an effective maintenance treatment [6]. In mCRC, this maintenance
strategy was tested in a phase II trial [7]… The present phase III trial was designed to compare …

SATURN: A double-blind, randomized, phase III study of maintenance erlotinib versus placebo following nonprogression with first-line platinum-based chemotherapy …

F Cappuzzo, T Ciuleanu, L Stelmakh… - Journal of Clinical …, 2009 - ascopubs.org
… Background: Erlotinib (E), a small-molecule EGFR TKI, is proven to extend survival versus
… The phase III SATURN study (BO18192) was initiated to evaluate E as maintenance therapy

[HTML][HTML] Maintenance erlotinib versus erlotinib at disease progression in patients with advanced non-small-cell lung cancer who have not progressed following …

S Cicènas, SL Geater, P Petrov, Y Hotko, G Hooper… - Lung Cancer, 2016 - Elsevier
… , placebo-controlled phase III trial of maintenance erlotinib versus erlotinib at the time of …
benefit observed in this trial, the use of maintenance treatment with erlotinib in patients with …

Efficacy and safety of maintenance erlotinib in Asian patients with advanced non-small-cell lung cancer: a subanalysis of the phase III, randomized SATURN study

YL Wu, JH Kim, K Park, A Zaatar, G Klingelschmitt… - Lung cancer, 2012 - Elsevier
… ; BO18192) study of erlotinib as maintenance treatment in … evaluated the efficacy and safety
of erlotinib in this setting. The … phase III SATURN study of erlotinib maintenance therapy, …

[HTML][HTML] Survival benefit with erlotinib maintenance therapy in patients with advanced non-small-cell lung cancer (NSCLC) according to response to first-line …

B Coudert, T Ciuleanu, K Park, YL Wu, G Giaccone… - Annals of oncology, 2012 - Elsevier
… Similar findings were reported in the phase III JMEN study of maintenance pemetrexed.
The HR for OS in patients with non-squamous NSCLC having SD after first-line chemotherapy …

Randomized, phase III study of gemcitabine or erlotinib maintenance therapy versus observation, with predefined second-line treatment, after cisplatin-gemcitabine …

M Pérol, C Chouaid, D Pérol, F Barlési… - Journal of Clinical …, 2012 - ascopubs.org
… This phase III study investigated whether continuation maintenance with gemcitabine or
switch maintenance with erlotinib improves clinical outcome compared with observation in …

… with or without erlotinib as maintenance therapy in patients with metastatic colorectal cancer (GERCOR DREAM; OPTIMOX3): a randomised, open-label, phase 3 trial

C Tournigand, B Chibaudel, B Samson… - The Lancet …, 2015 - thelancet.com
… the terms “erlotinib”, “bevacizumab”, “colorectal”, and “randomized”, and found one article
that reported on the same maintenance therapy regimen used in our study (Nordic ACT Trial). …

Approval summary: erlotinib maintenance therapy of advanced/metastatic non-small cell lung cancer (NSCLC)

MH Cohen, JR Johnson, S Chattopadhyay… - The …, 2010 - academic.oup.com
… If 50% of patients had EGFR + tumors by IHC (based on a phase III erlotinib trial in patients
with advanced NSCLC after failure of at least one prior chemotherapy regimen, wherein 47% …