The transcription cofactor c-JUN mediates phenotype switching and BRAF inhibitor resistance in melanoma

R Ramsdale, RN Jorissen, FZ Li, S Al-Obaidi… - Science …, 2015 - science.org
… of phenotype switching associated with drug resistance have not yet been clearly defined. It
is not clear whether phenotype switching … features, and phenotypic characteristics that could …

MYC cofactors: molecular switches controlling diverse biological outcomes

SR Hann - Cold Spring Harbor perspectives in …, 2014 - perspectivesinmedicine.cshlp.org
… is that a variety of cofactors form dynamic MYC transcriptional complexes that can switch the
… MYC is a member of a transcription factor family that includes MYCN and MYCL. MYCN has …

Multiple repressor pathways contribute to phenotypic switching of vascular smooth muscle cells

K Kawai-Kowase, GK Owens - American Journal of …, 2007 - journals.physiology.org
… is to identify the cis-regulatory elements and transcription factors that regulate transcription
of SMC selective/specific genes. Although numerous environmental cues, including growth …

The general transcription machinery and general cofactors

MC Thomas, CM Chiang - Critical reviews in biochemistry and …, 2006 - Taylor & Francis
… recognition ability to correctly specify the transcription start site unique to each gene…
transcription factors and general cofactors that help RNA polymerase II engage in the transcriptional

An update on the phenotypic switching of vascular smooth muscle cells in the pathogenesis of atherosclerosis

F Zhang, X Guo, Y Xia, L Mao - Cellular and Molecular Life Sciences, 2022 - Springer
transcription factors/co-factors of the phenotypic switching of VSMCs. The phenotypic switching
… a network of transcription factors/cofactors in the promoter regions of their genes. Three …

Controlling nuclear receptors: the circular logic of cofactor cycles

V Perissi, MG Rosenfeld - Nature reviews Molecular cell biology, 2005 - nature.com
… -mediated transcriptional regulation by focusing on the mechanisms that regulate the switch
from … Unfortunately, lack of space has not permitted a complete review of the phenotypic

Coordinated phenotype switching with large-scale chromosome flip-flop inversion observed in bacteria

L Cui, H Neoh, A Iwamoto… - Proceedings of the …, 2012 - National Acad Sciences
… To understand the mechanism of phenotypic switching, we … P1A) and conducted comparative
phenotypic and genetic … The transcriptional profiles and phenotypic expression of the …

Mechanistic insights into transcription factor cooperativity and its impact on protein-phenotype interactions

IL Ibarra, NM Hollmann, B Klaus, S Augsten… - Nature …, 2020 - nature.com
Transcription factor binding datasets Transcription factor (TF) binding data analyzed in
this work were collected from in vitro and in vivo studies. Specifically, CAP-SELEX and HT-SELEX …

[PDF][PDF] Identification of a Ctcf cofactor, Yy1, for the X chromosome binary switch

ME Donohoe, LF Zhang, N Xu, Y Shi, JT Lee - Molecular cell, 2007 - cell.com
… To test this idea, we carried out transcription assays in which … cofactors and work—at least
in part—through transcriptional … knockdown yields an identical phenotype in ES cells. Thus, we …

Resurrecting the role of transcription factor change in developmental evolution

VJ Lynch, GP Wagner - Evolution, 2008 - academic.oup.com
… If changes in transcription factor proteins are not responsible … we look for the source of
phenotypic variation? The answer, or … transcription factors, cofactors, and the basal transcriptional