The transcription cofactor c-JUN mediates phenotype switching and BRAF inhibitor resistance in melanoma
R Ramsdale, RN Jorissen, FZ Li, S Al-Obaidi… - Science …, 2015 - science.org
… of phenotype switching associated with drug resistance have not yet been clearly defined. It
is not clear whether phenotype switching … features, and phenotypic characteristics that could …
is not clear whether phenotype switching … features, and phenotypic characteristics that could …
MYC cofactors: molecular switches controlling diverse biological outcomes
SR Hann - Cold Spring Harbor perspectives in …, 2014 - perspectivesinmedicine.cshlp.org
… is that a variety of cofactors form dynamic MYC transcriptional complexes that can switch the
… MYC is a member of a transcription factor family that includes MYCN and MYCL. MYCN has …
… MYC is a member of a transcription factor family that includes MYCN and MYCL. MYCN has …
Multiple repressor pathways contribute to phenotypic switching of vascular smooth muscle cells
K Kawai-Kowase, GK Owens - American Journal of …, 2007 - journals.physiology.org
… is to identify the cis-regulatory elements and transcription factors that regulate transcription
of SMC selective/specific genes. Although numerous environmental cues, including growth …
of SMC selective/specific genes. Although numerous environmental cues, including growth …
The general transcription machinery and general cofactors
MC Thomas, CM Chiang - Critical reviews in biochemistry and …, 2006 - Taylor & Francis
… recognition ability to correctly specify the transcription start site unique to each gene…
transcription factors and general cofactors that help RNA polymerase II engage in the transcriptional …
transcription factors and general cofactors that help RNA polymerase II engage in the transcriptional …
An update on the phenotypic switching of vascular smooth muscle cells in the pathogenesis of atherosclerosis
F Zhang, X Guo, Y Xia, L Mao - Cellular and Molecular Life Sciences, 2022 - Springer
… transcription factors/co-factors of the phenotypic switching of VSMCs. The phenotypic switching
… a network of transcription factors/cofactors in the promoter regions of their genes. Three …
… a network of transcription factors/cofactors in the promoter regions of their genes. Three …
Controlling nuclear receptors: the circular logic of cofactor cycles
V Perissi, MG Rosenfeld - Nature reviews Molecular cell biology, 2005 - nature.com
… -mediated transcriptional regulation by focusing on the mechanisms that regulate the switch
from … Unfortunately, lack of space has not permitted a complete review of the phenotypic …
from … Unfortunately, lack of space has not permitted a complete review of the phenotypic …
Coordinated phenotype switching with large-scale chromosome flip-flop inversion observed in bacteria
… To understand the mechanism of phenotypic switching, we … P1A) and conducted comparative
phenotypic and genetic … The transcriptional profiles and phenotypic expression of the …
phenotypic and genetic … The transcriptional profiles and phenotypic expression of the …
Mechanistic insights into transcription factor cooperativity and its impact on protein-phenotype interactions
… Transcription factor binding datasets Transcription factor (TF) binding data analyzed in
this work were collected from in vitro and in vivo studies. Specifically, CAP-SELEX and HT-SELEX …
this work were collected from in vitro and in vivo studies. Specifically, CAP-SELEX and HT-SELEX …
[PDF][PDF] Identification of a Ctcf cofactor, Yy1, for the X chromosome binary switch
ME Donohoe, LF Zhang, N Xu, Y Shi, JT Lee - Molecular cell, 2007 - cell.com
… To test this idea, we carried out transcription assays in which … cofactors and work—at least
in part—through transcriptional … knockdown yields an identical phenotype in ES cells. Thus, we …
in part—through transcriptional … knockdown yields an identical phenotype in ES cells. Thus, we …
Resurrecting the role of transcription factor change in developmental evolution
… If changes in transcription factor proteins are not responsible … we look for the source of
phenotypic variation? The answer, or … transcription factors, cofactors, and the basal transcriptional …
phenotypic variation? The answer, or … transcription factors, cofactors, and the basal transcriptional …