… (16), indicating that targeted therapy may actually promote phenotype switching, potentially
… tumors are therapy resistant (17). The effects of phenotype switching on therapeutic outcome …

… origin of phenotype switching, we … phenotype switching. We also emphasized the need to
further develop this cancer biology field in order to identify new plausible therapeutic strategies…

… Here, we introduce treatment strategies based on macrophage phenotype regulation in
chronic diseases. With the knowledge of how to regulate the macrophage phenotype, we …

… therapies for long-term tumor control or eradication. In this work, we develop a mathematical
model to study how phenotypic switching at … and explore potential therapeutic strategies. We …

… Molecular basis and examples of epigenetically determined phenotypic switching ...........................................................................
288 Evolutionary consequences of phenotypic switching .......…

… However, to target phenotypic-switching through therapeutic intervention remains difficult.
Thus, the … of phenotype switching in the context of emerging and recently developed therapies. …

… induced by therapeutic antibodies. Here we investigated the dynamics of phenotypic switching
and … Adaptive therapy is an intermittent therapy strategy that limits the resistant subclones’ …

… Altogether, these findings show that targeting the senescence-like phenotype is considered
as an intriguing therapeutic strategy. Senolytics are a class of drugs that selectively eliminate …

… stable phenotypes of a cell. Straightforwardly, the phenotypic switching corresponds to the
… (or prevent) specific phenotype switching purposefully as a therapeutic strategy [31], which …

… therapy as a novel scheme to target not only combined cytotoxicity but also the rates of
phenotypic switching… for when designing such PHS therapeutic strategies: increasing \(w_{\…